Digital Repository

Epidemiology of non- alcoholic fatty liver disease (NAFLD) in an urban Sri Lankan population

Show simple item record

dc.contributor.author Dassanayake, A.S.
dc.contributor.author Rajindrajith, S.
dc.contributor.author Kasturiratne, A.
dc.contributor.author Kalubowila, U.
dc.contributor.author de Silva, A.P.
dc.contributor.author Mizoue, T.
dc.contributor.author Makaya, M.
dc.contributor.author de Silva, H.J.
dc.date.accessioned 2015-10-14T04:49:09Z
dc.date.available 2015-10-14T04:49:09Z
dc.date.issued 2008
dc.identifier.citation The Ceylon Medical Journal. 2008; 53(Supplement 1):25 en_US
dc.identifier.issn 0009-0875 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/10068
dc.description Oral Presentation Abstract (OP23), 121st Annual Scientific Sessions, Sri Lanka Medical Association, 2008 Colombo, Sri Lanka en_US
dc.description.abstract BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is increasing in the Asia-Pacific region. NAFLD can progress from simple steatosis, through steatohepatitis to advanced hepatic fibrosis, cirrhosis and hepatoma. Its prevalence in Sri Lanka is not known. Objective: To investigate community prevalence and risk factors associated with NAFLD among adults in an urban Sri Lankan population. DESIGN, SETTING AND METHODS: The sample consisted of 2985 randomly selected subjects, 35-65 years old, resident in the Ragama Medical Officer of Health area. NAFLD was diagnosed on ultrasound criteria (presence of 2 out of 3: increased hepatic echogenicity compared to spleen or kidney, blurring of hepatic vasculature, deep attenuation of ultrasound signal), and when alcohol intake was <14 units/week for males and <7 units/week for females. Anthropometric and blood pressure (BP) measurements were made; fasting blood glucose, lipid profile and serum alanine transaminase (ALT) were estimated (normal cutoff values were based on revised ATP III criteria of metabolic syndrome for Asians). RESULTS: 974(35%) individuals had NAFLD [mean age 52.8 years (SD 7.3), 605 (62.1%) females]. On multivariate analysis, central obesity (BMI>25kg/m2 and/or waist circumference >90cm for males, >80cm females), elevated fasting plasma glucose (>100mg/dl), elevated diastolic BP (>85mmHg), elevated plasma triglycerides (>150mg/dl), elevated ALT (>twice the upper limit of normal), and low high density lipoprotein cholesterol (<40mg/dl for men, <50mg/dl for women) were significantly associated with NAFLD. CONCLUSIONS: The prevalence of NAFLD among adults in this urban Sri Lankan community is as high as in western populations. NAFLD is associated with factors that constitute the metabolic syndrome. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject Non-alcoholic Fatty Liver Disease en_US
dc.subject Non-alcoholic Fatty Liver Disease-epidemiology en
dc.title Epidemiology of non- alcoholic fatty liver disease (NAFLD) in an urban Sri Lankan population en_US
dc.type Conference Abstract en_US


Files in this item

This item appears in the following Collection(s)

  • Conference Papers
    Papers presented at local and international conferences by the Staff of the Faculty of Medicine

Show simple item record

Search Digital Repository


Browse

My Account