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Clinical outcome of infection with L.donovani in Sri Lankan patients

Show simple item record Siriwardana, H.V.Y.D. Sirimanna, G. Udagedara, C. Chandrawansa, P.H. Wickremasinghe, A.R. Karunaweera, N.D. 2015-10-13T09:51:02Z 2015-10-13T09:51:02Z 2008
dc.identifier.citation The Ceylon Medical Journal. 2008; 53(Supplement 1):44 en_US
dc.identifier.issn 0009-0875 (Print)
dc.description Oral Presentation Abstract (OP61), 121st Annual Scientific Sessions, Sri Lanka Medical Association, 2008 Colombo, Sri Lanka en_US
dc.description.abstract OBJECTIVE: To describe the clinical profile of leishmaniasis in Sri Lanka. DESIGN, SETTING AND METHODS: This prospective descriptive study was conducted on incident cases of suspected cutaneous leishmaniasis (CL) referred to the Department of Parasitology, Faculty of Medicine, Colombo over 4 years. An interviewer administered questionnaire was administered to obtain clinical information. Diagnosis was confirmed with microscopy and/or PCR. RESULTS: Four hundred and one (401) patients with 549 lesions were studied. Over 70% lesions were parasitologically confirmed and further analyzed. The majority were soldiers (57.4%). The male to female ratio was 4:1. The majority were single lesions (73.9%) on exposed areas (forearms/hands- 44.1%), face/head/neck/pinna region-30.1%). Lesion included: papules (23.4%), nodules (25.4%), ulcerating nodules (19.6%), ulcers (23.7%), plaques (6.4%) and other types (1.7%). Non ulcerative lesions (NUL) were the commonest type observed up to 6 months. After 6-9 months, the proportion of ulcerative lesions was almost twice as that of NUL (60.8% vs 31.4%), Parasite positivity was highest in nodules (n=100, 75.5%), and in lesions of 5-9 months duration, and lowest in ulcers (n=92, 65.8%). After 12 months, the majority of leishmanial skin lesions either showed complete ulceration (44.1%) or remained non ulcerative (47.1%). Lesions in their 3rd year were mainly papules (42.9%) or ulcers (35.7%). Chronic lesions (>lyear) were mainly single. Sporo-trichoid spread (n=44, 11.9%), satellite lesions (n=35, 8.9%) and lymphatic spread (n=109, 27.7%) were observed. CONCLUSIONS: CL affects many provinces of the country, with most patients referred to this department from northern and southern provinces. Males comprised the majority of cases probably due to their higher risk due to exposure to outdoor biting habits of Phlebotomus sp. sand flies as an occupational hazard. The clinical spectrum of CL in Sri Lanka is wide. Parasitological confirmation of the diagnosis is important and investigations performed between 5-9 months of duration of a lesion may have higher chances of detecting parasites/parasite DNA. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject infection with L.donovani en_US
dc.title Clinical outcome of infection with L.donovani in Sri Lankan patients en_US
dc.type Article en_US

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