Digital Repository

Microscopic colitis not otherwise specified (NOS) in patients with diarrhoea predominant IBS in a tropical setting

Show simple item record

dc.contributor.author de Silva, A.P.
dc.contributor.author Dassanayake, A.S.
dc.contributor.author Hewavisenthi, J.
dc.contributor.author Liyanage, D.L.M.N.
dc.contributor.author Dissanayake, T.G.I.
dc.contributor.author Duminda, H.K.K.T.
dc.contributor.author de Silva, H.J.
dc.date.accessioned 2015-10-13T09:23:18Z
dc.date.available 2015-10-13T09:23:18Z
dc.date.issued 2008
dc.identifier.citation The Ceylon Medical Journal. 2008; 53(Supplement 1):39 en_US
dc.identifier.issn 0009-0875 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/10047
dc.description Oral Presentation Abstract (OP50), 121st Annual Scientific Sessions, Sri Lanka Medical Association, 2008 Colombo, Sri Lanka en_US
dc.description.abstract BACKGROUND: Coionoscopy is not recommended in IBS unless there are alarm symptoms. However, studies have shown that microscopic colitis and low grade inflammatory bowel disease (IBD) can mimic IBS. Microscopic colitis not otherwise specified (MNOS) is a distinct but poorly studied entity, especially in the tropics. OBJECTIVES: To investigate the presence of colonic and ileal inflammation in patients with diarrhea predominant IBS (IBS-D) in a tropicai setting. DESIGN, SETTING AND METHODS: In a prospective study over one year, we recruited 42 consecutive patients with IBS (diagnosed using Rome II criteria) and no alarm symptoms (mean age 36.1 yrs, M:F=29:13) and 13 controls {mean age 42.3 yrs, M:F=5:8). Serial colonic and ileal biopsies were obtained. RESULTS: Coionoscopy was macroscopically normal in all cases and controls. 23 (54.8%) cases had MNOS, 2(4.76%) ileal inflammation only, and 17(40.48%) had normal histology. Histology was normal in 11(84.62%) controls, and 2(15.38%) had MNOS. MNOS was significantly commoner in cases than controls (P=0.02, chi-square test). MNOS was commonest in the right side of the colon (n=20, 80%). 14(60.8%) patients with MNOS had a history suggestive of post infective IBS, compared to 7(36.8%) patients without MNOS (P>0.05). CONCLUSION: MNOS is common in patients with IBS-D in a tropical setting. Post infectious IBS seems commoner in patients with MNOS than those without MNOS, although this did not reach statistical significance. Coionoscopy with ileoscopy and serial biopsies are useful to detect mucosal inflammation in IBS-D. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject diarrhoea predominant en_US
dc.title Microscopic colitis not otherwise specified (NOS) in patients with diarrhoea predominant IBS in a tropical setting en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

  • Conference Papers
    Papers presented at local and international conferences by the Staff of the Faculty of Medicine

Show simple item record

Search Digital Repository


Browse

My Account