Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Pathological characteristics of lung tumors in Sri Lanka 2017-2021(Blackwell Publishing, 2024) Mathangasinghe, Y.; Wijayawardhana, S.; Perera, U.; Punchihewa, R.; Pradeep, S.The prevalence of lung cancer is steadily increasing globally, and it is projected to become the second most prevalent cancer in men by 2030. Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for approximately 3.61% of total fatalities. Despite its significant impact, many Asian countries, including Sri Lanka, lack precise data on the epidemiological patterns of lung tumors. This study pioneers a comprehensive exploration in Sri Lanka, delving into the demographic and clinicopathological characteristics of lung cancer patients. The study included 733 consecutive patients with lung tumors from 2017 to 2021, with a median age of 59 years. The most common site of tumors was the right lower lobe and left upper lobes. Adenocarcinoma was the most prevalent histopathological type of primary malignant lung tumors, while colorectal adenocarcinomas were the most common cause of metastatic deposits in the lungs. The most common benign tumor was hamartoma. Significantly, our findings unveiled associations between patient demographics and tumor types, underscoring the importance of factoring in age and gender in diagnostic assessments. Notably, the absence of a dedicated lung cancer screening program in Sri Lanka underscores the critical reliance on clinical suspicion and accurate diagnostic methods.Item Identifying the offending species in snakebite: a clinical score for use in community based epidemiological surveys(Sri Lanka Medical Association, 2004) Pathmeswaran, A.; Fonseka, M.M.D.; Kasturiratne, A.; Nandasena, S.; Gnanatilaka, G.K.; Gunaratne, L.; de Silva, A.P.; Lalloo, D.C.; de Silva, H.J.INTRODUCTION: Hospital data on snakebite fails to account for victims who do not reach hospital or who seek alternative treatment. In community surveys, identification of biting species is very difficult because the offending snake may sometimes not even be seen, is infrequently captured or killed, and antigen detection cannot be used in this setting. OBJECTIVE: To develop and validate a clinical score to identify biting species. METHODS: We identified 10 features relating to bites of the 6 venomous snakes in Sri Lanka (3 relating to circumstances of a bite and 7 clinical features of envenoming). Based on these, we developed a score applying different weightings to individual features depending on the species of snake. We then constructed 60 artificiaLdata sets containing different clinical scenarios, typical and atypical, for bites of a particular species. They were used to make adjustments to the score and determine cut-off values for identification (total ≥60/100 + difference of ≥5/100 from second highest score). The score was prospectively validated on 134 cases of snakebite with definite species identification, six months after the incident. RESULTS: Data were available from 25 cobra bites, 32 hump-nosed viper bites, 27 krait bites, 30 Russel's viper bites and 20 saw-scaled viper bites. Sensitivity/specificity of the score were: cobra 76/99, kraits 85/99, RV 70/99, HNV 97/83, SSV 100/83. 114 (85%) cases were correctly identified. 17 (12.7%) were misidentified, and 3 (2.3%) could not be identified. Conclusions: This score identifies the offending snake species with reasonable accuracy, and may be suitable for use in epidemiologicai surveys.