Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Clinical practice of vitamin D screening and supplementation in pregnancy in Asia-pacific countries: A cross-sectional study(Elsevier, 2023) Lee, R.W.K.; Chng, A.L.B.; Tan, K.H.; Shub. A.; Tan, T.; Ling, L.S.; Kuma, K.; Siew, C.Y.; Ting, W.; Myint, S.S.; Judistiani, R.T.D.; Shah, M.; Madulid-Sison, L.; Andres-Palencia, B.; Pagilagan-Palma, E.; Banu, L.A.; Boriboonhirunsarn, D.; Dias, T.D.BACKGROUND: Vitamin D deficiency is common in pregnant women. There is scarce information in the Asia-Pacific region on the understanding of vitamin D screening and supplementation in pregnancy among health care professionals. METHODS: We performed a cross-sectional study among health care professionals who are part of the Integrated Platform for Research in Advancing Metabolic Health outcomes of Women and Children (IPRMAHO) international study group on their understanding and perception of Vitamin D screening and supplementation in pregnancy. The cross-sectional survey comprised 4 main sections: demographics, existing policies, nutrient supplementation in pregnancy and various practices on screening, treatment and perceptions, with a total of 22 questions. A total of 15 responses were obtained from attendees from distinct health facilities across eleven participating Asia-Pacific countries. RESULTS: Majority of the surveyed hospitals (11/15, 78.6 %) did not have a national policy or regional guideline regarding Vitamin D screening and supplementation in pregnancy. More than half of respondents were (9/14, 64.3 %) were unsure of the percentage of women seen with Vitamin D deficiencies each year and were unsure of Vitamin D dosage prescribed to pregnant women with (8/15, 53.3 %) or without (6/14, 42.9 %) Vitamin D deficiency. Vitamin D was rarely prescribed in pregnancy when compared to other nutrient supplements such as folic acid and iron. Majority of respondents (9/11, 72.7 %) indicated that their hospital did not screen for Vitamin D deficiencies in pregnancy, even amongst high risk pregnant women. Nevertheless, majority of respondents indicated a need (12/15, 80.0 %) for a guideline or consensus regarding Vitamin D screening and supplementation in pregnancy. CONCLUSION: While majority of the surveyed hospitals did not have a national policy or regional guideline regarding Vitamin D screening and supplementation in pregnancy, majority of respondents indicated a need for the policy or guideline. There were varying clinical knowledge gaps and different perceptions on Vitamin D screening and supplementation in pregnancy among healthcare professionals.Item Vitamin D status and its association with serum parathyroid hormone in preschool children in a Sri Lankan Community(Sri Lanka Medical Assosiation, 2012) Marasinghe, E.; Chackrewarthy, S.; Abeysena, H.T.C.S.; Rajindrajith, S.INTRODUCTION: Despite increased awareness of the adverse health effects of low vitamin D status, data on serum vitamin D status of Sri Lankan preschool children is scarce. AIMS: To investigate the vitamin D status and its association with serum parathyroid hormone in preschool children in a community in the Ragama MOH area. METHODS: In a cross sectional study a total of 340 children (172 girls and 168 boys) aged 2-5 years were selected by random sampling. Fasting levels of serum vitamin D [as 25(OH)DJ and parathyroid hormone (PTH) were determined. The anthropometric characteristics of the children were measured using calibrated equipment. Statistical analysis was performed using SPSS 16.0. RESULTS: The mean fasting 25(OH)D and PTH concentrations were 23.47+8.9 ng/ml and 28.2±17.6 pg/ml respectively. 5.6% and 32.4% of the children had 25(OH)D concentrations indicative of vitamin D deficiency (<10 ng/ml) and insufficiency (10 - 20 ng/ml) respectively. 6% of the children were stunted and prevalence of wasting and" underweight were 17% and 14% respectively. Prevalence of stunting was significantly higher in girls (p<0.05J. Linear regression analysis showed a.significant inverse association between serum levels of 25(OH)D and PTH (r = -0.226, p<0.02). Intake of milk and diary foods had a positive association with 25(OH)D levels although statistically insignificant (r = 0.224, p>0.05). CONCLUSIONS: This study highlights the presence of sub-optimal vitamin D status in preschool children in a tropical country. Inverse changes in PTH may deleteriously affect skeletal development and growth. The need for appropriate interventions to optimise vitamin D status is emphasized.