Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Metabolic syndrome and risk of endometrial carcinoma among asymptomatic, postmenopausal, urban Sri Lankan females: a community cohort follow-up study(Wiley Publishing, 2017) Dias, T.; Niriella, M.; de Silva, S.; Motha, C.; Palihawadana, T.S.; Ediriweera, D.; de Silva, J.OBJECTIVES: Metabolic syndrome (MetS) has been recognised as a risk factor for malignancies. The aim of this study was to evaluate the association of MetS and risk of endometrial carcinoma (EC), by measuring endometrial thickness (ET). METHODS: The Ragama Health Study (RHS) recruited 35-64-year-old female cohort by age-stratified random sampling in 2007 and re-evaluated them in 2014, using a structured interview, anthropometric measurements and biochemical tests. Liver ultrasound to detect fatty liver was performed in 2007. Pelvic ultrasound to detect ET was performed in 2014 among consenting participants. MetS was diagnosed on established International Diabetes Federation (IDF 2012) criteria. Increased ET was defined as >5mm. Simple logistic regression was used to screen variables and multiple logistic regression was used to obtain adjusted effects of risk factors for increased ET. RESULTS: 813/1636(49.7%) of the original female cohort attended follow-up; ET was measured in 567(69.7%). Median (IQR) age of females was 61 (56-66) years. 323 fulfilled criteria for MetS (prevalence 57.1%) in 2007. 57(10.1%) had increased ET in 2014. Increasing plasma triglycerides [OR=1.004 per mg/dl, 95%CI:1.001-1.007, p<0.05] and being hypertensive [OR=2.16, 95%CI:1.11–4.08, p<0.05] were associated with increased ET, while advancing age [OR=0.93 per year, 95%CI:0.89–0.98, p<0.01] and being diabetic [OR= 0.34, 95%CI:0.10–0.89, p<0.05] were protective. CONCLUSIONS: Hypertension and increased plasma triglyceride levels, in the pre-menopausal period, were risk factors for future asymptomatic increased ET.Item Knowledge and awareness about gynaecological cancer(Sri Lanka College of Obstetricians and Gynaecologists, 2003) Padumadasa, S.; Goonewardene, M.INTRODUCTION: Gynaecological cancer (excluding breast cancer) accounts for about 10% of new cancer cases in women and 12% of cancer deaths. lack of awareness is a major factor in women with gynaecological cancer presenting to a doctor late. OBJECTIVE: to assess the knowledge and awareness about gynaecological cancer, SETTING, SUBJECTS AND METHOD: a total of 516 conse¬cutive women who attended the university gynaecology clinic at teaching hospital, mahamodera, galle during august and september 2002 were administered a pretested structured questionnaire. RESULTS: the knowledge about gynaecological cancer presenting as abnormal vaginal bleeding was poor. two-hundred and thirty six (45.8%) women thought that as one approaches menopause, irregular vaginal bleeding was normal. only 185 (35.8%) women knew that post-menopausal bleeding was abnormal. only 163 (31.5%) women knew that post-coital bleeding might be a symptom of cancer. two hundred and forty one (46.7%) women had heard about the cervix. only 89 (17.3%) knew that early marriage was a risk factor for cervical cancer while only 143 (27.7%) knew that multiple sexual partners was a risk factor for cervical cancer. only 27 (5.2%) were aware of the cervical smear. although 363 (70.3%) had heard about hormone replacement therapy (hrt), only 38 (7.4%) knew that there was an association with the occurrence of breast cancer and only 63 (12.2%) knew that there was a high risk of endometrial cancer if used inappropriately. only 134 (26.0%) women had heard about ovarian cancer. CONCLUSION: the knowledge about gynaecological cancer in women attending the university gynaecology clinic was poor. educational programmes in schools and community intervention programmes should be considered to increase the awareness about gynaecological cancer.