Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Response to neoadjuvant therapy in breast cancer: tumour regression and lymph node status(Sri Lanka Medical Association, 2002) Ratnayake, S.A.G.R.; Hewavisenthi, S.J.de S.BACKGROUND: Neoadjuvant therapy (NAT) prior to mastectomy is used to treat locally advanced breast carcinoma. This study assessed the response of breast cancer patients to NAT. METHODS: In a prospective study on 17 patients with carcinoma of the breast (16 females; age range 34—71 years) subjected to NAT prior to mastectomy, reduction in tumour size and the residual microscopic tumour percentage graded as, 0% - complete regression, 1-19% - marked regression, 20-79% - moderate regression, 80-99% - minimal regression, 100% - no regression, was assessed. Number of lymph nodes harvested and the number containing metastases (positivity) was compared with a control group of breast cancer patients (age and stage matched) undergoing mastectomy without NAT from a unit with a different treatment policy. RESULTS: Tumour size before NAT (mean 4.1cms) compared with that after NAT (mean l.Scms) was statistically significant (p<0.05). Microscopic assessment of residual tumour percentage showed 4 (23.5%) with complete regression, 2 (11.9%) with marked regression, 4 (23.5%) with moderate regression, 6 (35%) with minimum regression and 1 (5.8) with no regression. Neither the mean lymph node harvest of 11 (range 6-20) nor the mean lymph node positivity of 1.7 (range 0-8) in the NAT group were significantly different from values obtained for the control group [mean lymph node harvest 9.7 (range 4-18); mean lymph node positivity 2 (range 0-8)] (p>0.05). CONCLUSIONS: NAT causes macroscopic and microscopic reduction in tumour size in breast cancer. However, there is no significant difference on the therapeutic effect on axillary lymph nodes between patients receiving NAT and those undergoing mastectomy alone.Item Cadmium a metalloestrogen: are we convinced?(Wiley, 2012) Silva, N.; Peiris-John, R.; Wickremasinghe, R.; Senanayake, H.; Sathiakumar, N.Metalloestrogens are inorganic metal ions that bind to and activate oestrogen receptors. They are implicated in the aetiology of oestrogen-dependent diseases such as cancers of the breast and endometrium as well as endometriosis. Cadmium is one of the most studied metalloestrogens. In this review, scientific evidence for the oestrogenic effects of cadmium is critically evaluated to determine if there is sufficient evidence to support cadmium as an aetiological factor of oestrogen-dependent disease in humans. Results of the review indicated that, although the in vitro and in vivo evidence of the oestrogenic properties of cadmium was persuasive, evidence from population-based human studies remains conflicting. Considerable knowledge gaps exist on the potential oestrogenic effect of cadmium in humans. Research that focuses on bridging these knowledge gaps would be useful in preventing and managing oestrogen-dependent disease in humansItem New concepts of breast cancer aetiology(College of Surgeons of Sri Lanka, 2009) Ariyaratne, M.H.J.; Dilesha, W.A.L.No Abstract AvailableItem Locally advanced breast cancer as a possible portal of entry in a patient with tetanus(Sri Lanka Medical Association, 2007) Wijesuriya, S.R.E.; Wijesuriya, M.T.W.; Perera, M.T.P.R.; de Zylva, S.T.U.; Deen, K.I.No Abstract AvailableItem A Case of primary squamous carcinoma of breast(Sri Lanka Medical Association, 2005) Siriwardana, P.N.; Fernando, R.No Abstract Available