Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item 24 h activity guidelines in children and adolescents: A prevalence survey in Asia-Pacific cities(MDPI, 2023) Quah, P.L.; Loo, B.K.G.; Mettananda, S.; Dassanayake, S.; Chia, M.Y.H.; Chua, T.B.K.; Tan, T.S.Z.; Chan, P.C.; But, B.W.; Fu, A.C.; Wong, S.M.; Nagano, N.; Morioka, I.; Kumar, S.; Nair, M.K.C.; Tan, K.H.This study aimed to examine the prevalence of adherence to 24 h activity guidelines in children and adolescents from Asia-Pacific cities. In 1139 children aged 5-18 years, moderate-to-vigorous physical activity (MVPA), screen viewing time (SVT), sleep duration, child weight, height, sex, and age were parent-reported. Descriptive statistics were used to assess the number of guidelines met, and prevalence of adherence to activity guidelines by city and child sex. Prevalence of meeting all three 24 h activity guidelines was low across all countries (1.8-10.3%) (p < 0.05). Children from Thiruvananthapuram, India had the highest [10.3% (95% CI: 6.0-17.0)], while those from Tokyo, Japan had the lowest prevalence [1.8% (95% CI: 0.5-7.0)] of meeting all three guidelines. The highest prevalence of meeting individual MVPA, SVT and sleep guidelines was found in India [67.5% (95% CI: 58.8-75.1)], Kelaniya, Sri Lanka [63.2% (95% CI: 58.7-67.4)] and Kowloon, Hong Kong [59.4% (95% CI: 51.1-65.3)], respectively. Overall, a higher prevalence of boys met all three guidelines, compared to girls [5.9% (95% CI: 4.1-8.1) vs. 4.7% (3.1-6.6), p = 0.32]. The prevalence of adhering to all three activity guidelines was low in all five participating cities, with a higher proportion of boys meeting all guidelines.Item Thinness negatively affects lung function among Sri Lankan children(Public Library of Science, 2022) Senevirathna, N.; Amarasiri, L.; Jayamanne, D.; Manel, K.; Liyanage, G.Background: There have been conflicting findings on the effect of body mass index (BMI) on lung functions in children. Therefore, we studied the relationship between spirometry parameters and BMI among healthy Sri Lankan school children aged 5-7 years. Methods: A cross-sectional study was conducted among 296 school children (5-7-year-old) without apparent lung disease. Recruitment was done with stratified random sampling. Spirometry parameters, FEV1, FVC, PEFR, and FEV1/FVC ratio were determined. The acceptable and reproducible spirometry recordings were included in the analysis. Simple and multivariate linear regression analysis examined possible associations of lung function parameters with BMI, socio-demographic variables and indoor risk factors. Also, the mediator effect of gender on lung function through BMI was explored. Results: The participants' mean age (SD) was 6.4 (0.65) years. One-third were thin/severely thin (37%). A statistically significant difference in FVC (p = 0.001) and FEV1 (p = 0.001) was observed between BMI groups (obesity/overweight, normal, and thinness). Yet, PEFR or FEV1/FVC did not significantly differ among BMI groups (p = 0.23 and p = 0.84). Multivariate regression analysis showed that FEV1 and FVC were significantly associated with BMI, child's age, gender, family income, father's education, having a pet, and exposure to mosquito coil smoke. Interaction between gender and BMI for lung functions was not significant. The thin children had significantly lower FVC (OR: -0.04, 95%CI: -0.077, -0.012, p = 0.008) and FEV1 (OR: -0.04, 95%CI: -0.075, -0.014, p = 0.004) than normal/overweight/obese children. Family income demonstrated the greatest effect on lung functions; FVC and FEV1 were 0.25L and 0.23L smaller in low-income than the high-income families. Conclusion: Lower lung function parameters (FVC and FEV1) are associated with thinness than normal/overweight/obese dimensions among children without apparent lung disease. It informs that appropriate nutritional intervention may play a role in improving respiratory health.Item Auditory brainstem response for Sri Lankan children under 5 years of age: Normativedata(College of Otorhinolaryngologists and Head and Neck Surgeons of Sri Lanka, 2021) Ileperuma, L.D.; Weerasinghe, V.S.; Wickremasinghe, A.R.Abstract For years Sri Lankan Audiologists resorted to western norms in the interpretation of Auditory Brainstem Response (ABR) in the absence of national standards. The study focused on establishing normative data on ABR for Sri Lankan children below 5 years. ABR was performed on 258 healthy children between 6 weeks and 5 years of age to gather data on absolute latencies and inter-peak latencies.All inter-aural differences were within 0.2-0.4ms. The mean inter-aural difference for the study sample was significantly small (-0.0204ms to 0.0286ms). Mean values of absolute latencies for waves I, III, V for the 6-week age group at 30dBnHL were 3.33 ms, 5.91 ms and 8.27 ms respectively. Mean values of inter-peak latencies of wave I-III, III-V, I-V were 2.08 ms, 2.36 ms and 4.76 ms respectively for the 6-week age group at 30 dBnHL. The normative ABR data obtained in this study may be used across audiology clinics in Sri Lanka as a baseline measurement to diagnose hearing loss among children from infancy to 5 years of age when children are tested in their natural sleep and insert earphones are used. The mean value plus 2 standard deviations for each ABR measure may be used as the upper limit cutoff values. Hence this study helps eliminate misdiagnosis and under-diagnosis of hearing loss in children.