Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item The Health Effects of the Combined Use of Protein, Multivitamins and Electrolyte Dietary Supplements on Sri Lankan Athletes: A Pilot Study(Sri Lanka Medical Association, 2020) Fernando, P.N.J.; Pigera, S.; Rashani, S.A.N.; Niriella, M.A.; Jayawickreme, S.; de Silva, A.P.INTRODUCTION AND OBJECTIVES: The combine use of protein, multivitamins and electrolyte dietary supplements daily; multiple supplement (MS), is a common practice among Sri Lankan Athletes. The aim of this study was to determine the relative risk for developing adverse health effects from multiple supplements use. METHOD: A Retrospective Cohort, pilot study was conducted with 45 healthy athletes (23 males and 22 females), age between 22-31. Participants were composed of non-supplement users (n=19) and MS users for 2-5 months’ time (n=25). Their lipid, kidney, liver profiles, full blood count, fasting blood glucose, serum testosterone, urine full report and urine protein/creatinine were tested. Food frequency questionnaire was also filled from each athlete. RESULTS: Increase in total cholesterol and LDL cholesterol was significantly higher among multiple supplements users than non-users (P<0.05). Relative risk in increasing total cholesterol between 200-240 mg/dL was 8.7, increasing LDL cholesterol between 160-171 mg/dL was 2.9 and being overweight was 1.3, in MS users compared to non-users. Relative Risk in increasing total cholesterol was 2.9 in female and 7.1 in male while increasing LDL cholesterol was 2.3 in female and 4 in male. There were no statistically significant changes in the other parameters studied. CONCLUSION: Combined use of MS between 2-5 months, has a negative effect on the lipid profile of athletes. More pronounced in male. The clinical implication of this finding needs further study.Item Thyroglobulin epitope recognition in post iodine supplemented Sri Lanka population(Blackwell Scientific Publications, 2003) Okosime, O.E.; Premawardena, L.D.K.E.; Jayasinghe, A.; de Silva, D.G.H.; Smyth, P.P.A.; Parkes, A.B.; Lejeune, P.J.; Ruf, J.; Lazarus, J.H.OBJECTIVE: We previously reported a high prevalence of raised thyroglobulin autoantibodies (TgAb) in apparently healthy Sri Lankan schoolgirls following salt iodination. To characterize these antibodies further we determined the epitopes on thyroglobulin (Tg) with which they react and compared these with serum obtained from both healthy subjects and established autoimmune thyroid disease (AITD) patients from the UK. To extend our study to a wider population within Sri Lanka, we in addition determined the epitopes recognized by a group of AITD patients selected from a thyroid clinic in Sri Lanka, as well as apparently healthy female Sri Lankan tea workers of distinct ethnicity from the schoolgirls and AITD patients. DESIGN: Sri Lankan schoolgirls (n = 282) and adult female tea estate workers (n = 208) were examined for thyroid autoimmune markers. Sera with high TgAb (> 98 kIU/l) were selected from these two groups (n = 36 and 45, respectively) to study epitope-binding patterns. We also examined the sera from 16 AITD patients attending a thyroid clinic in Colombo, 16 patients with AITD from the thyroid clinic at the University Hospital of Wales and 16 sera from healthy control UK women with no evidence of thyroid disease. To determine the epitopes on Tg recognized by the subjects' TgAb, we employed a panel of Tg mouse monoclonal antibodies labelled with alkaline phosphatase in a competitive enzyme-linked immunosorbent assay reaction with the subjects' serum. RESULTS AND CONCLUSIONS: A majority of the Sri Lankan schoolgirls did not react with the immunodominant epitopes and did not differ significantly from healthy subjects from the UK in their Tg epitope recognition pattern. On the other hand, tea estate workers and Sri Lankan AITD patients recognized typical autoimmune thyroid disease epitopes and, in addition, recognized a separate cluster not previously associated with either the autoimmune state or the healthy state. The significance of this cluster requires further clarification