Medicine

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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty

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Author: search.filters.author.de Silva, H.J.Subject: search.filters.subject.Hepatitis, Viral, Human

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Now showing 1 - 4 of 4
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    Hepatitis C Infection
    (Sri Lanka College of Microbiologists, 2006) de Silva, H.J.
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    Hepatitis B, C, and HIV infections in Sri Lanka
    (Ceylon College of Physicians, 2006) de Silva, H.J.; Abeywickrema, I.
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    Hepatitis B and C virus markers among new entrant medical students
    (Sri Lanka Medical Association, 1999) Premawardhena, A.P.; Premaratna, R.; Jayaweera, G.; Costa, S.; Chandrasena, L.G.; de Silva, H.J.
    AIM: To investigate the presence of hepatitis B and C virus markers in new entrant medical students at the Faculty of Medicine, University of Kelaniya. METHOD: 456 students (mean age 24 years, SD 3.5, 257 men) were investigated before they were exposed to clinical work, using a questionnaire to assess sociodemographic factors and possible risk factors for contracting hepatitis B or C. Blood samples were tested for HBs Ag and anti HBs (n = 456), and anti-HCV (n = 162 randomly selected samples) with a third generation sandwich radioimmunoassay technique. RESULTS: The students were from 20 of the 25 districts in the country, although their distribution was not inform. A past history of hepatitis or jaundice was obtained from 24 (5.3 percent ) and 6 (1.3 percent ) students respectively. None of them had been vaccinated against hepatitis B. At least one risk factor for hepatitis B or C was present in 32 (7 percent ) of them. None of the samples were positive for HBsAg or anti-HCV, and only two (0.44 percent ) were positive for anti-HBs. CONCLUSION: Our results support the view that exposure to hepatitis B and C seems to be uncommon in this country, at least up to young adulthood. As most new entrant medical students are not immune to these infections there is a strong case to vaccinate them against hepatitis B before they are exposed to clinical work.
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    Viral hepatitis complicating pregnancy--a five year hospital based retrospective study
    (Sri Lanka Medical Association, 1993) de Silva, H.J.; Jayawardena, J.; Pethiyagoda, A.U.; Pethiyagoda, C.J.B.; Sirisena, J.L.
    Limited data are available on viral hepatitis (VH) complicating pregnancy from Sri Lanka. We retrospectively studied all pregnant and non-pregnant women of child bearing age, who were admitted with VH to the Teaching Hospital Peradeniya between January 1987 and December 1991. During this period, there were 187 cases of icteric VH among non-pregnant women of child bearing age, but only 10 cases among pregnant women (hospital incidence of 0.35 cases of VH per 1000 pregnancy related admissions). Two of the 10 (case fatality 20%) pregnant women died of causes related to VH compared with only 3 of the 187 (1.6%) non-pregnant women (p < 0.001), giving a relative risk of death due to VH in pregnant women of 12.5 (95% confidence limits 1.8-85.6). The perinatal case fatality rate due to VH was 20%. VH complicating pregnancy does not appear to be a common cause of hospital admission, but pregnancy makes death due to VH more likely. VH complicating pregnancy also results in a high perinatal mortality
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