Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Albendazole in the treatment of goehelminth infections in children(Sri Lanka Medical Association, 1989) de Silva, D.G.H.; Hettiarachchi, S.P.; Fonseka, P.H.Children with mixed helminthic infections between the ages of 2 and 14 years, from a slum area, were treated with two regimes of albendazole. A majority of children had moderate to heavy infections with Trichuris trichiura (greater than 70%) and Ascaris lumbricoides (greater than 84%). Children treated with a single 400 mg dose of albendazole showed a very good response in ascariasis with 100% cure rate irrespective of the severity of infection. In Trichuriasis (n = 40), a cure rate of 50% was observed in mild infections, but only a reduction in the egg counts of 60% and 57% respectively were observed in moderate and heavy infections. Only 10 patients with Necator americanus infections were treated with the single dose, and the cure rate in mild infections was satisfactory (86%), with an overall egg reduction rate of 95%. In 47 children included in the multiple dose regime (200 mg daily x 3 days), the cure rates in trichuriasis were, 82%, 66%, and 37% respectively in mild, moderate, and heavy infections. The egg reduction rate was 98% in all degrees of infection in trichuriasis. The cure rate in ascariasis, with the multiple dose regime was similar to that of the single dose, with 100% egg reduction, irrespective of the severity of infection.Item An Evaluation of the potency of Osbeckia octandra and Melothria maderaspantana as antihepatotoxic agents.(George Thieme, 1989) Jayathilake, K.A.; Thabrew, M.I.; Pathirana, C.; de Silva, D.G.H.; Perera, D.J.Aqueous extracts of the aerial parts of Melothria maderasptana and the leaves of Osbeckia octandra have been compared with (+)-3-cyanidanol with regard to their abilities to alleviate carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by comparing the abilities of these drugs to protect the liver against CCl4-mediated alterations in the liver histopathology and serum levels of aspartate aminotransferase (GOT), alkaline amino-transferase (GPT), and alkaline phosphatase. In both pretreatment and post-treatment (administration of drugs before or after CCl4 treatment) experiments, the most marked rate of recovery of the liver was exhibited by the group of rats treated with Melothria maderaspatana extract. Although the protection offered by (+)-3-cyanidanol and Osbeckia octandra appears to be comparable in post-treatment, Osbeckia was significantly more effective in pre-treatment. From the overall results obtained it appears that the aqueous extracts of Melothria maderaspatana and Osbeckia octandra are both as potent or in some instances (in pretreatment experiments) more potent than (+)-3-cyanidanol. Of the two plants tested under the present experimental conditions used, Melothria maderaspatana appears to be marginally more effective than Osbeckia octandra in protecting the liver against CCl4-induced alterations.Item Non-accidental injuries to children in Sri Lanka(Sage Publishing, 1988) Chandrasiri, N.; Lamabadusuriya, S.P.; de Silva, D.G.H.No abstract AvailableItem Single dose treatment of mixed helminth infections--a comparison of three different regimes(Sri Lanka Medical Association, 1987) de Silva, D.G.H.; Lionel, N.D.; Premaratne, U.N.; Warnasuriya, N.; Soysa, P.E.; Fonseka, P.H.No abstract availableItem Congenital lipodystrophy (Seip syndrome) in Sri Lanka(Sri Lanka Medical Association, 1984) de Silva, D.G.H.No abstract availableItem Rota virus associated carbohydrate intolerance in Sri Lankan children(Sri Lanka Medical Association, 1984) de Silva, D.G.H.; Mendis, L.; Soysa, P.No abstract availableItem Flubendazole in the treatment of Ascaris lumbricoides and Trichuris trichiura: a comparison of two different regimens with single-dose(Sri Lanka Medical Association, 1984) de Silva, D.G.H.; Lionel, N.D.; Jayatilleka, S.M.No Abstract AvailableItem Chronic brucellosis in a farmer(Sri Lanka Medical Association, 1981) de Silva, D.G.H.; Wijeratne, U.No Abstract AvailableItem The Prevalence and severity of soil transmitted helminths in an urban slum community in Colombo(Sri Lanka Medical Association, 1981) de Silva, D.G.H.; Jayatilleka, S.M.No abstract availableItem Disaccharidase activities in jejunal fluid(British Medical Association, 1983) Aramayo, L.A.; de Silva, D.G.H.; Hughes, C.A.; Brown, G.A.; McNeish, A.S.Jejunal fluid and mucosal tissue were obtained simultaneously from the same jejunal site in a group of 29 children by a modified biopsy procedure. Lactase, maltase, and sucrase activities were measured in both fluid and mucosal specimens using the same analytical method. The fluid enzyme activities showed highly significant positive correlations with the same enzyme activity in the relevant tissue samples. Relative concentrations of disaccharidase enzymes represented by sucrase: lactase activity ratios also showed a highly significant positive correlation between fluid and tissue. This close relation suggests that the mucosa is the sole or predominant source of disaccharidase activity in the intestinal fluid. The results of kinetic studies comparing tissue and fluid enzyme characteristics also indicate a mucosal origin for the fluid enzyme activities. We conclude that disaccharidase activities in jejunal fluid reflect closely local tissue values and that these measurements may be useful in assessing mucosal enzyme activity in infants in whom jejunal biopsy is not possible