Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Maternal sleep deprivation is a risk factor for small for gestational age: a cohort study(Wiley-Blackwell, 2009) Abeysena, C.; Jayawardana, P.; Senevirathne, R. de A.AIMS: To determine trimester-specific risk factors for small-for-gestational-age (SGA) infants. METHODS: A population-based prospective cohort study was conducted in Sri Lanka from May 2001 to April 2002. Pregnant women were recruited on or before 16 weeks of gestation and followed up until delivery. The sample size was 690. Trimester-specific exposure status and potential confounding factors were gathered on average at 12th, 28th and 36th weeks of gestation. SGA was assessed using customised birth centile charts. Multiple logistic regression was applied, and the results were expressed as odds ratios (OR) and 95% confidence intervals (95%CI). RESULTS: The risk factors for SGA less than 5th centile were shift work and exposure to physical and chemical hazards during 2nd and 3rd trimesters (OR 4.20, 95%CI 1.10-16.0), sleeping for less than or equal to 8 h during 2nd or 3rd or both trimesters (OR 2.23, 95%CI 1.08-4.59), walking for less than or equal to 2.5 h per day (OR 2.66, 95%CI 1.12-6.31) and alcohol consumption during the 3rd trimester (OR 14.5, 95%CI 2.23-94.7). Poor weekly gestational weight gain was significantly associated with both SGA < 10th and < 5th centiles. None of the other factors became significant for SGA < 10th centile. CONCLUSIONS: Risk factors for SGA less than 5th centile were sleep deprivation and shift work and exposure to physical and chemical hazards during 2nd and 3rd trimesters, less walking hours and alcohol consumption during 3rd trimester. Poor weekly gestational weight gain may be considered as a predictor of delivering an SGA infant.Item Risk factors for spontaneous abortion(College of Community Physicians of Sri Lanka, 2009) Abeysena, C.; Jayawardana, P.; Senevirathne, R. de A.OBJECTIVE: To determine the risk factors for spontaneous abortion. STUDY DESIGN: A prospective cohort study was carried out in Sri Lanka ITom May 2001 to April 2002 determine the risk factors for spontaneous abortion. Eight hundred and twenty pregnant mothers were recruited on or before 16 weeks of gesta¬tion and followed up until delivery. Socio-demographic, occupational exposures, psychosocial stress and physical activity in terms of posture during pregnancy were assessed. Logistic regression analysis was applied and results were expressed as odds ratios (OR) and 95% confidence intervals (95%CI). RESULTS: Maternal age of> 35 years was a risk factor [OR 2.98; 95%CI: 1.07,8.26] and walking> 2.5 hours/day was a protec¬tive factor [OR 0.31; 95%CI: 0.11, 0.92] for second trimester spontaneous abortions after controlling for confounding factors. Occupational exposures, psychosocial stress, alcohol consumption or exposure to passive cigarette smoke during pregnancy were not observed to have an association. CONCLUSIONS: Maternal age of>35 years was and less walking hours/day were risk factors for spontaneous abortion