Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item A Methodical approach to medical terminology(Authour, 2009) Salgado, S.; Athukorala, U. V.No abstract availableItem Neurovascular bundle of upper limb for medical undergraduates(Salgado, S., 2009) Salgado, S.; Abeysuriya, V.No abstract availableItem Approaches to the multiple choice questions in histology(Authour, 2011) Salgado, S.No abstract availableItem Item Item Item Item Hemoglobin A1c values in CKDu endemic and non endemic regions of Sri Lanka(Elsevier Science Publishers, 2017) Wijerathne, B.; Meier, R.; Salgado, S.; Agampodi, S.Item Utrastructural changes of foetal surface of the placenta in hypertensive disorders of pregnancy(Sri Lanka Medical Association, 1997) Salgado, S.; Angunawala, P.; de Tissera, A.OBJECTIVES : The pathogenesis of pregnancy induced hypertension and its relationship to pathological and ullrastructural changes of the placenta has not been adequately understood We studied placenta! (issue from foetal side to show whether there are any significant ullrastructural changes. This area of the placenta has not been studied previously. METHODS: Placenial tissue from 15 pregnant mothers with a persistent blixxi pressure of 140/90 or more, and 10 normal mothers who had normal full term deliveries were studied. Fresh placentae were examined macroscopically. 2mm sized section were taken from (lie central, foetal surface and fixed in 2% gluteraldehyde lor electron microscopic studies. RESULTS: 9 months had pregnancy induced hypertension without proteinuria, 3 had hypertension and proteinuria and oilier 3 had essential hypertension. All hypertensive placenta showed increased number of cytotrophoblast cells. Syncytiotrophoblast cells of the hypertensive placenta showed Jess number of lipoid droplets, compared to the controls. Syncliotrophoblast cells of the test group also showed short, blunt and swollen microvilli. All hypertensive placentae except one, showed thickened, laminated and irregular subirophoblasu'c basement membranes and increased amount of interestitial collagen in the villous stroma CONCLUSIONS: In electron microscopic study of normal and hypertensive placentae revealed that the placentas of hypertensive disoalers pregnancy is associated with increased number of cytotrophoblast cells, thickening of subtrophoblastic basement membrane, abnormal microvilli, and increased amunt on interestitial collagenItem Interaction between pericytes and endothelial cell of foetal capillaries in hypertensive placentae(Sri Lanka Medical Association, 1998) Salgado, S.; Angunawela, P.; Sirisena, J.; de Tissera, A.INTRODUCTION : Pericytes and endothelial cells are known to possess direct contacts in many parts of the vascular tree. Pericytes are known to have modulating effects on endothelial cell growth and differentiation. It is possible that some pericytes are a source of new endothelial cell. OBJECTIVES : Information regarding the ultrastructural changes of foetal capillaries of hypertensive placentae is lacking. Therefore we studied the foetal capillaries of hypertensive placentae to ascertain any significant ultrastructural interaction between pericytes. endothelial cells and basement membrane. METHOD : Placental tissue from 15 pregnant mothers with a blood pressure of 140/90 or more and 10 normal mothers who had normal full term deliveries were studied. Fresh placentae were examined and 2mm sized pieces were taken from central foetal and fixed in 2% gluteraldehyde for eletron microscopic studies. RESULTS : All hypertensive placentae showed a number of pericytic processes, which was significantly higher than in normal placentae. (P<0.001). Both frequency and complexity of direct connections between endothelial cells and pericytes appear to be increased in foetal capi 1 laries of hypertensive placentae . Basement membranes of foetal capillaries in 9 hypertensive placentae showed marked thickening. CONCLUSIONS : There was complexed interaction between endothelial cells and pericytes of foetal capillaries of hypertensive placentae.