Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Diuretic activity of leaf and stem decoctions of Anisomeles indica(2003) Dharmasiri, M.G.; Ratnasooriya, W.D.; Thabrew, M.I.Anisomeles indica (Lamiaceae) is a wild perennial herb growing in South and South East Asia. A decoction of leaves and stems of this plant is said to be diuretic but this point has not been verified in a controlled scientific investigation. The aim of the study was to scientifically investigate the diuretic activity of the decoctions of leaves and stems of both preflowering (E1) and flowering (E2) plants. Rats were used for experiments. The results showed that A. indica has powerful diurecti action and justify the use of the plant in traditional medicine in Sri Lanka. It is concluded that only the preflowering plants possessed marked diuretic activity. The selection of proper stage of the plant is vital for the induction of diuresis.Item Water extracts of leaves and stems of pre-flowering but not flowering plants possess analgesic and antihyperalgesic activities in rat(Informa Healthcare, 2003) Dharmasiri, M.G.; Ratnasooriya, W.D.; Thabrew, M.I.According to Sri Lankan traditional medicine, a decoction made from stems and leaves of Anisomeles indica Kuntze (Lamiaceae) possesses analgesic activity. However, the validity of this claim has not been scientifically tested. The aim of this study was to investigate analgesic and antihyperalgesic activities of this plant using a water extract made from the leaves and stems. The water extracts were made from leaves and stems of both preflowering (E1) and flowering plants (E2). E1 showed a dose-dependent analgesic effect up to 6 h of treatment when tested in rats using the hot plate and the tail flick techniques. Further, the analgesic effect of E1 was not accompanied by toxic effects. This effect was neither gender dependent nor dependent on the stage of the estrous cycle. E1 also showed a dose-dependent antihyperalgesic activity in the hot plate test. In contrast, E2 did not show any analgesic effect (500 mg/kg). The analgesic effect produced by E1 was not abolished by naloxone. E1 dose-dependently retarded the amplitude of the spontaneous contractions of isolated dioestrous rat uterus. Further, E1 induced a dosedependent plasma membrane stabilisation effect on rat erythrocytes. Collectively, these observations suggest that the analgesic and antihyperalgesic effects of E1 are mediated from inhibition of COX-1, thus impairing the synthesis of prostaglandins. A change in chemical contents that accompanies flowering could be one possible reason for the inability of E2 to demonstrate analgesic effect.