Medicine
Permanent URI for this communityhttp://repository.kln.ac.lk/handle/123456789/12
This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
Browse
2 results
Search Results
Item Pathological characteristics of lung tumors in Sri Lanka 2017-2021(Blackwell Publishing, 2024) Mathangasinghe, Y.; Wijayawardhana, S.; Perera, U.; Punchihewa, R.; Pradeep, S.The prevalence of lung cancer is steadily increasing globally, and it is projected to become the second most prevalent cancer in men by 2030. Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for approximately 3.61% of total fatalities. Despite its significant impact, many Asian countries, including Sri Lanka, lack precise data on the epidemiological patterns of lung tumors. This study pioneers a comprehensive exploration in Sri Lanka, delving into the demographic and clinicopathological characteristics of lung cancer patients. The study included 733 consecutive patients with lung tumors from 2017 to 2021, with a median age of 59 years. The most common site of tumors was the right lower lobe and left upper lobes. Adenocarcinoma was the most prevalent histopathological type of primary malignant lung tumors, while colorectal adenocarcinomas were the most common cause of metastatic deposits in the lungs. The most common benign tumor was hamartoma. Significantly, our findings unveiled associations between patient demographics and tumor types, underscoring the importance of factoring in age and gender in diagnostic assessments. Notably, the absence of a dedicated lung cancer screening program in Sri Lanka underscores the critical reliance on clinical suspicion and accurate diagnostic methods.Item Using red cell indices as a screening test for the detection of haemoglobin E trait in population screening for haemoglobin disorders(Sri Lanka Medical Association, 2005) Premawardhena, A.; Samarakoon, S.; Perera, U.; Samaranayake, R.; Arambepola, M.INTRODUCTION: When screening populations for haemoglobin E trait, which is found in up to 5% in some regions in Sri Lanka, some believe that the full blood count with red cell indices, demonstrating hypochromasia and microcytosis (MCV<80fl and MCH< 27pg), is not sensitive enough, as up to 5% may be missed. If this is true, more complicated and expensive tests will be necessary to detect Hb E trait. There are no studies which have attempted to test the efficacy of red cell indices as a screening test for Hb E trait in Sri Lanka AIMS: To test the sensitivity of the full blood count with red cell indices as a screening test for the detection of haemoglobin E trait MATERIALS AND METHODS: Individuals diagnosed to have Hb E trait by the usage of high performance liquid chromatography (HPLC) - (Bio Rad) had their red cell indices measured using an automated cell counter (Coulter, Act Diff III) RESULTS: 47 Individuals with Hb E trait were identified using HPLC analysis. 28 were females (59%). The haemoglobin levels ranged from 10.5 to 15.4 g/dl. (Mean 12.6). There was only one individual with an MCV of 80, whilst the rest had values below that. MCV values ranged from 58-80fl. There were 3 individuals with an MCH over 27 (27.4, 28.8 and 27.4). The individual with an MCV of 80 had an MCH of 27.4. CONCLUSIONS: In this ongoing study we found that by using a cutoff point for MCV at 80ft up to 2% of individuals with Hb E trait will be missed. As the screening test needs to be more sensitive than this, we suggest that by using a slightly higher cutoff point for the MCV (eg. 81 fl) we would still be able to detect individuals with Hb E trait using red cell indices, thus minimizing cost.