Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Obstetric emergencies a practical manual(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract availableItem Shoulder dystocia.(Sri Lanka college of Obstetricians & Gynaecologists, 2021) Padumadasa, S.; Wijesinghe, P.S.No abstract availableItem Perimortem caesarean delivery(Sri Lanka college of Obstetricians & Gynaecologists, 2021) Kodithuwakku, K.A.S.U.A.; Padumadasa, S.No abstract availableItem Acute pancreatitis in pregnancy – Nip in the bud (Case Reports)(Sri Lanka college of Obstetricians & Gynaecologists, 2021) Padumadasa, S.; Siriwardana, R.C.No abstract availableItem Internal iliac artery ligation – time to revive a dying art(Sri Lanka College of Obstetricians & Gynaecologists, 2020) Padumadasa, S.No Abstract availableItem Acute and subacute toxicity studies of the Ethyl Acetate soluble proanthocyanidins of the immature inflorescence of Cocos nucifera L. in female Wistar Rats.(Hindawi Pub. Co., 2019) Ekanayake, C.P.; Thammitiyagodage, M.G.; Padumadasa, S.; Seneviratne, B.; Padumadasa, C.; Abeysekera, A.M.Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.Item Precision of predicting expected date of delivery by ultrasound scan in comparison to last menstrual period(Sri Lanka College of Obstetricians & Gynaecologists, 2014) Wasalathilaka, C.; Kumari, S.D.T.L.; Palihawadana, T.S.; Herath, H.M.R.P.; Padumadasa, S.; Pathmeswaran, A.; Dias, T.D.INTRODUCTION: Estimation of the expected date of delivery (EDD)is important in management of pregnancy, as many clinical decisions would rely on the estimated gestation of the fetus. In routine clinical practice, this is done by either adding the duration of a pregnancy to the last menstrual period (LMP) or by assessment of fetal biometry by an early pregnancy ultrasound scan (USS). The accuracy of these methods can be assessed either by correlating the dates with people with a know date of conception, such as following IVF, or by study of the correlation with the date of delivery in a cohort of women who goes in to spontaneous labour. In this study we have assessed the accuracy of the two methods by the latter approach. The aim of this study was to assess the agreement of EDD calculated by LMP or USS, to the date of delivery in spontaneous labour. METHODS: This was a retrospective cohort study. 675 patients who had a spontaneous onset of labour were included in the analysis. USS fetal crown rump length was considered for gestational age assessment between 8 and 14 weeks and fetal head circumference considered thereafter. Their agreement of the date of delivery with the estimated expected date of delivery by LMP or USS was assessed. RESULTS: Spontaneous delivery was seen with 6 days of the USS EDD and 7 days of the LMP EDD in 50% of women and within 11days of USS EDD and 15days of LMP EDD among 75% of women. A delivery within 14 date of the EDD was observed in 93.7% when USS EDD was considered and it was only in 86.2% with the LMP EDD (OR 2.40, 95%CI 1.64-3.52). CONCLUSION: This study demonstrate that the USS EDD is more in agreement with the date of spontaneous delivery than the EDD estimated from LMP. This highlights the importance of dating USS in all pregnancies which would be helpful in management of pregnancy in late stages.Item Transplacental transfer of dengue(Sri Lanka Medical Association, 2014) Ekanayake, C.D.; Padumadasa, S.; Premaratna, R.; Rajindrajith, S.; Samaranayake, W. W.