Medicine
Permanent URI for this communityhttp://repository.kln.ac.lk/handle/123456789/12
This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
Browse
2 results
Search Results
Item The Health Effects of the Combined Use of Protein, Multivitamins and Electrolyte Dietary Supplements on Sri Lankan Athletes: A Pilot Study(Sri Lanka Medical Association, 2020) Fernando, P.N.J.; Pigera, S.; Rashani, S.A.N.; Niriella, M.A.; Jayawickreme, S.; de Silva, A.P.INTRODUCTION AND OBJECTIVES: The combine use of protein, multivitamins and electrolyte dietary supplements daily; multiple supplement (MS), is a common practice among Sri Lankan Athletes. The aim of this study was to determine the relative risk for developing adverse health effects from multiple supplements use. METHOD: A Retrospective Cohort, pilot study was conducted with 45 healthy athletes (23 males and 22 females), age between 22-31. Participants were composed of non-supplement users (n=19) and MS users for 2-5 months’ time (n=25). Their lipid, kidney, liver profiles, full blood count, fasting blood glucose, serum testosterone, urine full report and urine protein/creatinine were tested. Food frequency questionnaire was also filled from each athlete. RESULTS: Increase in total cholesterol and LDL cholesterol was significantly higher among multiple supplements users than non-users (P<0.05). Relative risk in increasing total cholesterol between 200-240 mg/dL was 8.7, increasing LDL cholesterol between 160-171 mg/dL was 2.9 and being overweight was 1.3, in MS users compared to non-users. Relative Risk in increasing total cholesterol was 2.9 in female and 7.1 in male while increasing LDL cholesterol was 2.3 in female and 4 in male. There were no statistically significant changes in the other parameters studied. CONCLUSION: Combined use of MS between 2-5 months, has a negative effect on the lipid profile of athletes. More pronounced in male. The clinical implication of this finding needs further study.Item Do common arishta preparations manufactured in Sri Lanka contain anabolic androgenic steroids (AAS), stimulants or ethanol?(Sri Lanka Medical Association, 2018) Fernando, P.N.J.; Pigera, S.; Rashani, S.A.N.; Fernando, R.; Weerasinghe, D.P.P.; Godakumbura, K.K.D.T.D.; Niriella, M.A.; Jayawickreme, S.; de Silva, A.P.INTRODUCTION AND OBJECTIVES: The common arishta preparations which are available in the local market are .'Ashwagandharishta', 'Balarishta' and 'Dashamoolarishta'. These contain a wide range of chemical constituents including alkaloids and steroidal lactones. Moreover, fermented decoctions and infusions are also used in ayurveda therapeutics and the fermentation process as well generates alcohol. The possible presence of substances prohibited within the world anti-doping agency (WADA) code in the arishta preparations may threaten the careers of athletes who consume herbal supplements. The objective of this study is to analyse commonly available arishta samples for the presence of prohibited AAS, stimulants as per WADA code and determination of ethanol content. METHODS: Compounds were segregated by adjusting pH after dissolving in methanol. Organic layer was evaporated and residue was reconstituted with derivatizing agent. The derivatized solutions were utilized for gas chromatography- mass spectrometry (GC-MS) analysis. In addition to that ethanol content of arishta samples was quantified by using gas chromatography. RESULTS: The GC-MS studies showed the absence of prohibited AAS and stimulants in the arishta samples analysed. Moreover, glycerol and ethanol were identified to be present in all samples and ethanol content of the all arishta samples was (5.80 - 8.35 ±0.5) % (v/v) and the limit of detection was about 2 g/ml. CONCLUSION: This study showed the absence of any AAS or stimulants as per the WADA code in the arishta samples analysed. However, alcohol content below 8.35±0.5% (v/v) was detected. To the best of our knowledge this is the first study showing these findings.