Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Validity of the Sinhala version of the general health questionnaires item 12 and 30: Using different sampling strategies and scoring methods(Ibn Sina Academy of Medieval Medicine & Sciences, 2016) Abeysena, H.T.C.S.; Jayawardana, P.L.; Peiris, M.U.P.K.; Rodrigo, A.OBJECTIVE: To determine the criterion validity of the Sinhala version of the General Health Questionnaire-12 (GHQ-12) and GHQ-30 employing different sampling designs and scoring methods. METHODS: This was a descriptive cross-sectional study including 374 patients. The GHQ-30 was completed by the participants using likert scale and then converted into standard score. The ‘Clinical Examination’ was done blindly to the GHQ score as the reference standard. Total study sample was considered as a representative sample taken consecutively. Case-reference design included 126 cases and 126 randomly selected controls based on reference standard. Test result-based designs included two groups of positive and negative GHQ, based on the optimal cut-off level. Cut-off levels were determined by using three criteria. In addition stratum specific likelihood (SSLR) ratio also considered. RESULTS: Applying consecutive sampling design, for the GHQ-12, the optimal cut-off levels were 9/10 using likert score and 2/3 using standard score and for the GHQ-30, 25/26 using likert score and 6/7 using standard score. The optimal cut-off level depends on the different sampling designs employed in addition to criteria for determining cut-off levels. The SSLR of>1 was useful for determining optimal cut-off level. Irrespective of the scoring methods, application of case-reference design tends to be overestimation of the specificity with high threshold values and test result-based design tends to be overestimation of the sensitivity, compared to consecutive sampling. Using likert scoring method, the sensitivities were higher than standard scoring method. CONCLUSIONS: The optimal cut-off levels depend on the sampling design and the scoring method employed and criteria to determine cut-off levels.Item Knowledge of basic epidemiological and statistical concepts among doctors in selected Sri Lankan hospitals(College of Community Physicians of Sri Lanka, 2010) Abeysena, H.T.C.S.; Jayawardana, P.L.; Wickremasinghe, A.R.; Wickramasinghe, U.INTRODUCTION: This study was conducted to describe the ability to comprehend basic epidemiologic and statistical concepts among doctors in selected hospitals in the Western Province. METHODOLOGY: A cross-sectional descriptive study was conducted during January to February, 2008. The study population consisted of 315 doctors - 43 (13.7%) specialists, 50 (16%) postgraduate trainees (PG) and 222 (70.3%) grade medical officers. A self administered questionnaire was used to assess perceived knowledge on selected epidemiologic and statistical concepts/parameters and two problem based questions which tested the ability to apply knowledge were used. Data were analyzed calculating the proportion who perceived to have good knowledge regarding each concept. Logistic regression was applied to test for differences in good knowledge between different groups of subjects. RESULTS: More than 75% of the respondents claimed to have good knowledge on prevalence, sensitivity, specificity and case control studies. Less than 50% of them had good knowledge on risk difference, number needed to treat, systematic reviews, meta-analysis, p-value and 95% confidence intervals. Male doctors had a significantly higher good knowledge than female doctors (p<0.001), and those who read medical journals regularly than those who did not (p<0.05). Specialists and PG trainees had a significantly higher good knowledge (p<0.001) than grade medical officers. Correct answers of the respondents to the two problem based questions were 25% (n=79) and 15.8% (n=50), respectively. CONCLUSION : Even though some doctors claimed to have a good knowledge with regard to selected epidemiologic and statistical concepts, their ability to apply their knowledge was poor.Item Ventilatory function in brass workers of Gadaladeniya Sri Lanka(Oxford University Press, 1997) Jayawardana, P.L.; de Alwis, W.R.; Fernando, M.A.A cross sectional study was conducted to determine the respiratory hazards of brass workers. The study group was selected randomly. The control group was selected from the general population matched for age by cluster sampling. There was a total of 154 pairs for the final analysis. A questionnaire was administered to determine the prevalence of respiratory symptoms. Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1.0), forced expiratory flow rate in the mid 50% of the FVC(FEF25%-75%) and peak expiratory flow rate(PEFR) were measured. Chest radiography was performed on those with 5 or more years of service. Cough, phlegm, chronic bronchitis and dyspnoea were significantly higher among brass workers. The ventilatory capacity was significantly lower in all the indicators except FVC. Smoking had no significant effect and a dose response relationship could not be demonstrated after inclusion of age in the regression model. Five point five per cent had evidence of septal lines while 6.4% had emphysema.