Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Knowledge and lifestyle adaptations to COVID-19 among tea plantation owners in Balangoda, Sri Lanka(Faculty of Medicine, University of Kelaniya, Sri Lanka, 2021) Dharmalingam, L.; Chandrasekera, C.; Pramodya, S.; Gamage, P.; Fernando, C.; Prathapan, S.Introduction: COVID-19 pandemic is the current global health crisis with a socioeconomic impact around the world. Tea plantation owners need adequate knowledge of COVID-19 to prevent its spread in tea estates and sustain their economy during the pandemic. Objectives: The objective was to describe the knowledge and lifestyle adaptations to COVID-19 among tea plantation owners in Balangoda, Sri Lanka Methods: A descriptive cross-sectional study, was conducted among 85 tea plantation owners of a Tea Estate Development Society in Sri Lanka. Simple random sampling technique was used. Data was collected using a self-administered questionnaire comprising of participant’s sociodemographic data, effect of COVID-19 on estate economy (during March to August 2020 compared to 2019), knowledge, lifestyle adaptations to COVID-19 and chronic diseases among the participants. Data was analysed using SPSS software. The significance level was set at 5%. Results: Most of the participants had poor knowledge and lifestyle adaptations to COVID- 19 (50.6%). No significant association was found between knowledge of CO VID-19 and sociodemographic data such as age (p=0.579), gender (p=0.263), education level (p=0.941) and monthly income (p=0.082). Majority (56.0%) had a positive effect on estate economy during March to August 2020 compared to 2019. No significant association was found between poor knowledge of COVID-19 and poor effect on estate economy due to COV ID- 19 (p= 0.365). Statistical significance was observed between the presence of diabetes and poor knowledge of COVID-19 (p=0.049). Conclusions: Majority of the tea plantation owners lack adequate knowledge and lifestyle adaptations to COVID-19. Thus, it is essential to improve the knowledge among them.Item Histopathological spectrum in acute and chronic cutaneous leishmaniasis in Sri Lanka(Sri Lanka College of Microbiologists, 2015) Manamperi, N.H.; de Silva, M.V.C.; Fernando, C.; Pathirana, K.P.N.; Abeyewickreme, W.; Karunaweera, N.D.OBJECTIVES: To describe the histological spectrum of acute and chronic cutaneous leishmaniasis. METHOD: Patients from Sri Lanka army were recruited by active and passive case detection methods and punch biopsies were obtained. Skin biopsies of 35 patients with smear positive for Leishmania amastigotes were processed routinely for histopathology, examined at a conference microscope and classified into 4 groups using modified Ridley criteria for Leishmaniasis as: I - parasitized macrophages with variable lymphocytes and plasma cells; II - parasitized macrophages with lymphocytes, plasma cells and ill formed histiocytic granulomata; III -a mixture of macrophages (with or without parasites), lymphocytes, plasma cells and epithelioid granulomata; IV - epithelioid granulomatous response with a few lymphocytes and plasma cells but no amasigotes. Lesions were categorized as acute (<6 months) or chronic (> 6 months). RESULTS: Study group composed of males with a mean age of 32.6 years (range 22-47) and lesion duration of 5.6 months (range 1-24). Twenty nine (82.9%) were also positive by histopathology. Twenty two (62.9%) were acute and 13 (37.1%) chronic. Group I, II, III and IV patterns were seen in 14 (40%), 12 (34.3%), 5 (14.3%) and 4 (11.4%) respectively and 9 (40.9%), 9 (40.9%), 2 (9.1%) and 2 (9.1 %) of acute lesions and 5 (38.5%), 3 (23.1 %), 3 (23.1 %) and 2 (15.4%) of chronic lesions respectively. CONCLUSION: Histology of cutaneous leishmaniasis shows marked inflammatory cell infiltrate with or without granuloma formation. Majority of patients presenting with either acute or chronic cutaneous leishmaniasis belong to histological groups I or II. ACKNOWLEDGEMENTS: Financial assistance from the University Grants Commission, Sri Lanka (UGC/VC/DRIC/PG/2013/KLN/ 03) and University of Kelaniya (RP/03/04/06/01/2014) are acknowledged. An abstract based on similar work was presented at the 128"1 Anniversary International Medical Congress of the Sri Lanka Medical Association, 5th to 8th July 2015.Item Histopathological spectrum in acute and chronic Cutaneous Leishmaniasis in Sri Lanka(Sri lanka Medical Association, 2015) Manamperi, N.H.; Fernando, C.; Pathirana, K.P.N.; Karunaweera, N.D.; Abeyewickreme, W.; de Silva, M.V.C.INTRODUCTION AND OBJECTIVES: Histological spectrum in cutaneous leishmaniasis (CL) is wide and varied. The objective of this study is to describe the histological spectrum of acute and chronic CL. METHOD: Skin biopsies of 35 patients with smear positive for Leishmania amastigotes were processed routinely for histopathology, examined at a conference microscope and classified into 4 groups using modified Ridley criteria for Leishmaniasis as: I- parasitized macrophages with variable lymphocytes and plasma ceils; 1! - parasitized macrophages with lymphocytes, plasma cells and ill formed histiocytic granulomata; 111 - a mixture of macrophages (with or without parasites), lymphocytes, plasma cells and epithelioid granulomata; IV - epithelioid granulomatous response with a few lymphocytes and plasma cells but no amastigotes. Lesions were categorized as acute (< 6 months) or chronic (> 6 months). RESULTS: Study group composed of all males with a mean age of 32.6 years (range 22 - 47) and lesion duration of 5.6 months (range 1-24). Twenty nine (82.9%) were also positive by histopathology. Twenty two (62.9%) were acute and 13 (37.1%) chronic. Group I, II, Ml and IV patterns were seen in 14 (40%), 12 (34.3%), 5 (14.3%) and 4 (11.4%) respectively and 9 (40.9%), 9 (40.9%), 2 (9.1%) and 2 (9.1%) of acute lesions and 5 (38.5%), 3 (23.1%), 3 (23.1%) and 2 (15.4%) of chronic lesions respectively. CONCLUSION: Histology of CL shows marked inflammatory cell infiltrate with or without granuloma formation. Majority of patients presenting with either acute or chronic CL belong to histological groups I or II.