Medicine
Permanent URI for this communityhttp://repository.kln.ac.lk/handle/123456789/12
This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
Browse
3 results
Search Results
Item Anti-inflammatory and analgesic activity in the polyherbal formulation maharasnadhi quathar(Elsevier, 2003) Thabrew, M.I.; Dharmasiri, M.G.; Senaratne, L.Maharasnadhi Quathar (MRQ) is a polyherbal preparation recommended by Ayurvedic medical practitioners for treatment of arthritic conditions. An investigation has been carried out with rats and human rheumatoid arthritis (RA) patients, to determine the anti-inflammatory and analgesic potential of MRQ. Results obtained demonstrate that MRQ can significantly and dose-dependently inhibit carrageenan-induced rat paw oedema (the inhibition at 3h was greater than at 1h after induction of oedema). MRQ could also increase the reaction time of rats in the hot-plate test (by 57% after the first hour of treatment), although it had no effect on the reaction time in the tail-flick test, indicating that MRQ possesses analgesic activity that is probably mediated via a supra-spinal effect.MRQ also exerted a dose-dependent (a) protective effect on heat-induced erythrocyte lysis, and (b) inhibition of 5-lipoxygenase activity. In RA patients, after 3 months of MRQ treatment, there was a marked improvement in the pain and inflammation experienced by the patients as well as in the mobility of the affected joints. From the overall results obtained, it may be concluded that MRQ possesses significant anti-inflammatory and analgesic activities. Alteration in synthesis of prostaglandins and leukotrienes, membrane stabilization and anti-oxidant activity are some of the possible mechanisms through which MRQ mediates its anti-arthritic effects.Item Diuretic activity of leaf and stem decoctions of Anisomeles indica(2003) Dharmasiri, M.G.; Ratnasooriya, W.D.; Thabrew, M.I.Anisomeles indica (Lamiaceae) is a wild perennial herb growing in South and South East Asia. A decoction of leaves and stems of this plant is said to be diuretic but this point has not been verified in a controlled scientific investigation. The aim of the study was to scientifically investigate the diuretic activity of the decoctions of leaves and stems of both preflowering (E1) and flowering (E2) plants. Rats were used for experiments. The results showed that A. indica has powerful diurecti action and justify the use of the plant in traditional medicine in Sri Lanka. It is concluded that only the preflowering plants possessed marked diuretic activity. The selection of proper stage of the plant is vital for the induction of diuresis.Item Water extracts of leaves and stems of pre-flowering but not flowering plants possess analgesic and antihyperalgesic activities in rat(Informa Healthcare, 2003) Dharmasiri, M.G.; Ratnasooriya, W.D.; Thabrew, M.I.According to Sri Lankan traditional medicine, a decoction made from stems and leaves of Anisomeles indica Kuntze (Lamiaceae) possesses analgesic activity. However, the validity of this claim has not been scientifically tested. The aim of this study was to investigate analgesic and antihyperalgesic activities of this plant using a water extract made from the leaves and stems. The water extracts were made from leaves and stems of both preflowering (E1) and flowering plants (E2). E1 showed a dose-dependent analgesic effect up to 6 h of treatment when tested in rats using the hot plate and the tail flick techniques. Further, the analgesic effect of E1 was not accompanied by toxic effects. This effect was neither gender dependent nor dependent on the stage of the estrous cycle. E1 also showed a dose-dependent antihyperalgesic activity in the hot plate test. In contrast, E2 did not show any analgesic effect (500 mg/kg). The analgesic effect produced by E1 was not abolished by naloxone. E1 dose-dependently retarded the amplitude of the spontaneous contractions of isolated dioestrous rat uterus. Further, E1 induced a dosedependent plasma membrane stabilisation effect on rat erythrocytes. Collectively, these observations suggest that the analgesic and antihyperalgesic effects of E1 are mediated from inhibition of COX-1, thus impairing the synthesis of prostaglandins. A change in chemical contents that accompanies flowering could be one possible reason for the inability of E2 to demonstrate analgesic effect.