Journal/Magazine Articles

Permanent URI for this collectionhttp://repository.kln.ac.lk/handle/123456789/13

This collection contains original research articles, review articles and case reports published in local and international peer reviewed journals by the staff members of the Faculty of Medicine

Browse

Filters

Settings

Author: search.filters.author.Hewavisenthi, S.J.de S.Has files: No

Search Results

Now showing 1 - 10 of 30
  • No Thumbnail Available
    Item
    Continuing medical education (CME) in pathology: the role of the college of pathologists of Sri Lanka.
    (College of Pathologists of Sri Lanka., 2003) Hewavisenthi, S.J.de S.; de Silva, M.V.C.
    No Abstract Available
  • No Thumbnail Available
    Item
    Colonoscopic ultrasound is associated with a learning phenomenon despite previous rigid probe experience
    (Springer India, 2009) Siriwardana, P.N.; Hewavisenthi, S.J.de S.; Pathmeswaran, A.; Deen, K.I.
    Colonoscopic ultrasound (CUS) enables total colonoscopic examination combined with staging of tumor. Rigid probe transrectal ultrasound (TRUS) is reliable in assessing rectal cancer. Both the modalities are associated with an initial learning curve. We evaluated the predictability CUS in preoperative staging of rectal cancer during the learning curve, despite experience with TRUS. Forty-four patients with non-obstructing rectal cancer were assessed by colonoscopy and colonic ultrasound using a 7.5 MHz rotating transducer. Accuracy of ultrasound staging was compared with pathological staging. Tumor staging and nodal staging at pathology and ultrasound were named pT, pN and uT, uN, respectively. The pathological staging was pT1 in two (4.5%), pT2 in 16 (36%), pT3 in 21 (48%) and pT4 in five (11.5%) rectal cancer specimens. CUS understaged the tumor in 11 cases and overstaged it in 10 cases. Overall, the positive predictive value was 61%, negative predictive value 73%, sensitivity 61%, and specificity 73%. Lymph nodes were not visualized in 14. The overall un-weighted kappa of CUS staging of RC was 0.18 (poor). The predictive value in tumor staging of CUS is suboptimal in the learning phase, despite previous experience with TRUS.
  • No Thumbnail Available
    Item
    Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays
    (Springer-Verlag, 2010) Aloysius, M.M.; Hewavisenthi, S.J.de S.; Bates, T.E.; Rowlands, B.J.; Lobo, D.N.; Zaitoun, A.M.
    BACKGROUND: Morphometry [nuclear Ki-67 labelling, mitotic activity index (MI), and volume-corrected mitotic index (M/V)] for periampullarycancers using tissue microarrays has not been performed previously. The purpose of the study was to assess these indices on tissue microarray (TMA) sections constructed from patients with periampullary cancers and study their association with clinicopathological variables. METHODS: Immunohistochemical staining for Ki-67 was performed on formalin-fixed pancreatic TMA sections. Expression of Ki-67 was assessed as the percentage of cancer cell nuclei expressing MIB1, MI as the mean percentage of Ki-67 from 10 random high-power fields, and M/V was calculated after standardizing MI for connective tissue volume and microscope parameters in the tumor using established protocols. RESULTS: Patients > or =70 years with periampullary cancers had higher Ki-67 expression (>15) compared with patients <70 years of age (chi(2) = 3.9, P = 0.047). Ki-67 expression was higher in tumors > or =2 cm (chi(2) = 4.9, P = 0.028) compared with smaller tumors. Higher MI (>15) was clearly associated with worsening histological grade (chi(2) = 9.2, P = 0.010). The median survival for tumors of the pancreaticobiliary subtype (pancreatic ductal adenocarcinoma and cholangiocarcinoma) was 43 months in the group with an M/V score of <20, compared with 18 months for the group with a score > or =20 (P = 0.001). There was no statistically significant difference in survival, based on M/V score, for tumors of the intestinal subtype (ampullary and duodenal adenocarcinoma). CONCLUSIONS: In periampullary cancers, Ki-67 and MI are proliferative indices predictive of tumor behavior. M/V was predictive of survival in tumors of the pancreaticobiliary subtype.
  • No Thumbnail Available
    Item
    Incidence of inflammatory bowel disease in Gampaha district: details of the Sri Lankan component of the Asia-Pacific Crohn's and Colitis Epidemiology Study
    (Sri Lanka Medical Association, 2014) Kasturiratne, A.; Mufeena, M.N.; Mettananda, K.C.D.; Fernandopulle, N.; Rajindrajith, S.; Waraketiya, P.R.; Weerasinghe, S.K.; Ranaweera, A.; Hewavisenthi, S.J.de S.; de Silva, A.P.; de Silva, H.J.
    The aim of this report is to provide details of the methodology and results of the Sri Lankan component of the Asia-Pacific Crohn's and Colitis. Epidemiology Study. Fourteen state and private hospitals with specialist services in the Gampaha and Colombo districts were kept under surveillance over a 12 month period to recruit patients with newly diagnosed Inflammatory Bowel Disease (IBD) who were permanent residents of the Gampaha district. Thirty five cases (ulcerative colitis-21, Crohn's disease-13, IBD-undetermined-1) were detected, giving a crude annual IBD incidence of 1.59 per 100,000 population.
  • No Thumbnail Available
    Item
    Usefulness of routine terminal ileoscopy and biopsy during colonoscopy in a tropical setting: a retrospective record-based study
    (Hindawi Publishing Corporation, 2014) Wijewantha, H.S.; de Silva, A.P.; Niriella, M.A.; Wijesinghe, N.; Waraketiya, P.; Kumarasena, R.S.; Dassanayake, A.S.; Hewavisenthi, S.J.de S.; de Silva, H.J.
    Introduction. Available evidence for routine terminal ileoscopy during colonoscopy is equivocal. We investigated the place of routine terminal ileoscopy and biopsy during colonoscopy, in a tropical setting. Materials and Methods. All consenting adults undergoing colonoscopy had routine TI and biopsy. Patients with right iliac fossa (RIF) pain, diarrhoea, anaemia, suspected inflammatory bowel disease (IBD), and raised inflammatory markers were defined as Group A and all others undergoing colonoscopy as Group B. Results. Caecal intubation and TI were achieved in 988/1096 (90.15%) and 832/1096 (75.9%) cases, respectively. 764/832(91.8%) patients were included in final analysis. 81/764 (10.6%) patients had either macroscopic (34/81) or microscopic (47/81) abnormalities of terminal ileum; 20/81 had both. These were CD (28/47), tuberculosis (TB) (6/47), ileitis due to resolving infection (8/47), and drug-induced ileitis (5/47). 27/81 with macroscopically normal ileum had CD (18/27), ileitis due to resolving infection (5/27) and drug-induced ileitis (4/27) on histology. 12/764 (1.57%) patients with macroscopically normal colon had ileal CD (8/12), drug-induced ileitis (2/12), and resolving ileal infection (2/12) on histology. 47/764 (6.15%) patients had ileal pathology that influenced subsequent management. These were significantly higher in Group A (43/555 (8%)) than in Group B (4/209 (1.9%)) (P = 0.0048, χ (2) = 7.968). Conclusion. TI and biopsy improve diagnostic yield of colonoscopy in patients with RIF pain, diarrhoea, anaemia, suspected IBD, and raised inflammatory markers.
  • No Thumbnail Available
    Item
    Subspecialization in histopathology: The Sri Lankan perspective
    (College of Pathologists of Sri Lanka, 2013) Hewavisenthi, S.J.de S.; Beneragama, D.H.
    No Abstract Available
  • No Thumbnail Available
    Item
    Histological study of macroscopically normal mucosa adjacent to tumour in colorectal resection specimens
    (College of Pathologists of Sri Lanka, 2012) Ratnayake, R.M.U.S.; Hewavisenthi, S.J.de S.
    OBJECTIVE: To study the histological features of macroscopically normal mucosa in colorectal carcinoma specimens and attempt to correlate the severity of these changes and the distance of the mucosa from the tumour. METHOD: Ninety three resection margins from 52 specimens were categorized according to the distance from the tumour, 0-1cm, 1.1-5cm and more than 5cm. The histological parameters assessed included, lymphoid aggregates, acute inflammation, chronic inflammation, crypt distortion and villous change. These were graded as absent, mild, moderate and severe. The presence of intraepithelial lymphocytes, cystically dilated ducts and epithelial erosions were recorded as absent or present. Results were analyzed using Pearson Chi- square test and Fischer-Exact statistics. .RESULTS: The histological features found included, lymphoid aggregates in 40% acute inflammation in 15% chronic inflammation in 16% crypt distortion 17%, cystically dilated glands 21%, epithelial erosion 13% and villous change 32%. The presence of cystically dilated glands showed a significant correlation with the distance from the tumour. CONCLUSION: Varied histopathological features were observed in the mucosa adjacent to the tumour, awareness of which can prevent misinterpretation and over diagnosis of these features.
  • No Thumbnail Available
    Item
    Synovial sarcoma [Letter to the Editor]
    (College of Pathologists of Sri Lanka, 2012) Mahendra, B.A.G.G.; Hewavisenthi, S.J.de S.
    No Abstract Available.
  • No Thumbnail Available
    Item
    Granulomatous colitis: Can pathology help in differentiating intestinal tuberculosis from Crohns disease ?
    (College of Pathologists of Sri Lanka, 2012) Hewavisenthi, S.J.de S.
    No Abstract Available
  • No Thumbnail Available
    Item
    Is Past exposure to hepatitis a protective against progressive fibrosis in non-alcoholic fatty liver disease?
    (Wiley-Blackwell, 2008) de Silva, A.P.; Kasturiratne, A.; Liyanage, D.L.; Karunanayaka, T.K.; Hewavisenthi, S.J.de S.; Dassanayake, A.S.; Farrell, G.C.; de Silva, H.J.
    No Abstract Available