Journal/Magazine Articles
Permanent URI for this collectionhttp://repository.kln.ac.lk/handle/123456789/13
This collection contains original research articles, review articles and case reports published in local and international peer reviewed journals by the staff members of the Faculty of Medicine
Browse
2 results
Search Results
Item Ultrastructure of endothelial cells of fetal capillaries of placentae of women with pregnancy induced hypertention(University of Colombo, 2006) Salgado, S. S.; Angunawela, P.; de Tissera, A.; Sirisena, J.The present study aimed to compare the ultra structural features of endothelial cells of fetal terminal capillaries of placentae from hypertensive (n=10) and non-hypertensive (n=10) pregnancies. The ultrastructural features of endothelial cells of terminal capillaries from the fetal surface of each placenta were examined under the electron microscope. Micrographs of 8 different endothelial cells from each placenta were prepared for evaluation by stereological analysis using a coherent double lattice test system. The volume fractions of different organelles and cytosol in endothelial cells of placental fetal capillaries of both hypertensive and non-hypertensive pregnancies were deter¬mined by counting the number of grid intersection points falling on the endothelial cell cytoplasm, mitochondria, rough endoplasmic reticulum and glycogen deposits. Ultrastructural changes were noted in endothelial cells of capillaries of placentae of mothers with pregnancy induced hypertension. Statistical analysis showed that the volume fractions of the organelles and the amount of cytoplasm of endothelial cells of placentae from hypertensive pregnancies were significantly higher than those from non-hypertensive pregnanciesThere was a significant increase in some of the organelles and the capacity of cytoplasm of endothelial cells of placentae from hypertensive pregnancies when compared to normotensive pregnancies. These findings may be attributed to compensatory mechanisms operating as a response to hypoxia caused by reduced maternal blood flow to the placenta.Item Villous syncytial knots in hypertensive placenta(Sri Lanka College of Obstetricians and Gynaecologists, 2004) Salgado, S. S.; Angunawela, P.; de Tissera, A.; Sirisena, J.Syncytial knots are seen on many terminal villi of all mature placentae. Syncytial knots in more than 30 percent of mature terminal villi, is considered as an indication of postmaturity. The aim of this study was to find out whether there is significant increase in syncytial knot formation in pre-eclampsia and to assess the relationship between syncytial knot formation and maternal age, parity, and period of gestation and effects of syncytial knots on the birthweight, and apgar score of the newborn. The study sample consisted of 150 normal and 200 hypertensive mothers. Light microscopic studies were done on sections taken from fetal surface of their placentae. Hundred terminal villi in fetal subdivisions of each placenta were counted and the number of villi with syncytial knots was recorded. Multivariate analysis was done to find out the difference between the number of placentae with high syncytial knot counts in normal and hypertensive groups and the relationship between high syncytial knot counts and the maternal age, parity, period of gestation and birthweight, head circumference and apgar score of the newborn. Statistically significant increase of syncytial knot counts was seen in hypertensive group than the normal group. There was no relationship between syncytial knot formation and maternal age and parity. In normal and hypertensive groups, an increase in the number of placentae with high syncytial counts was observed with increasing maturity. Although the number of placentae with high syncytial knot counts were higher in relation to low apgar score than the normal counts, difference was not statistically significant. A significant difference in the birth weight and the head circumference of newborns in relation to normal and high syncytial knot counts was observed in hypertensive group.