Conference Papers

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This collection contains abstracts of conference papers, presented at local and international conferences by the staff of the Faculty of Medicine

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1998 - 20002

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Author: search.filters.author.Angunawela, P.Has files: No

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    Interaction between pericytes and endothelial cell of foetal capillaries in hypertensive placentae
    (Sri Lanka Medical Association, 1998) Salgado, S.; Angunawela, P.; Sirisena, J.; de Tissera, A.
    INTRODUCTION : Pericytes and endothelial cells are known to possess direct contacts in many parts of the vascular tree. Pericytes are known to have modulating effects on endothelial cell growth and differentiation. It is possible that some pericytes are a source of new endothelial cell. OBJECTIVES : Information regarding the ultrastructural changes of foetal capillaries of hypertensive placentae is lacking. Therefore we studied the foetal capillaries of hypertensive placentae to ascertain any significant ultrastructural interaction between pericytes. endothelial cells and basement membrane. METHOD : Placental tissue from 15 pregnant mothers with a blood pressure of 140/90 or more and 10 normal mothers who had normal full term deliveries were studied. Fresh placentae were examined and 2mm sized pieces were taken from central foetal and fixed in 2% gluteraldehyde for eletron microscopic studies. RESULTS : All hypertensive placentae showed a number of pericytic processes, which was significantly higher than in normal placentae. (P<0.001). Both frequency and complexity of direct connections between endothelial cells and pericytes appear to be increased in foetal capi 1 laries of hypertensive placentae . Basement membranes of foetal capillaries in 9 hypertensive placentae showed marked thickening. CONCLUSIONS : There was complexed interaction between endothelial cells and pericytes of foetal capillaries of hypertensive placentae.
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    Histological and ultra-structural changes in enpothelial cells of the placenta in hypertensive disorders of pregnancy
    (Sri Lanka Medical Association, 2000) Salgado, L.S.S.; Angunawela, P.; Tissera, A.; Sirisena, J.
    INTRODUCTION: The maternal syndrome of pre-eclampsia is thought to result from a generalized vascular endothelial cell disturbance caused by a circulating factor probably derived from the placenta. Objective: Study the histological and ultra-structural changes of endothelial cells, so that the contribution of these changes to the pathogenesis of hypertensive disorders of pregnancy can be understood. METHOD: Placentae of 150 normal pregnancies and 200 hypertensive disorders of pregnancy were selected for this study. Tissue from the fetal surface was obtained for microscopic examination. Electron microscopic examination was done on 20 normal placentae and 30 placentae from hypertensive disorders of pregnancy. RESULTS: Histologically there were no significant changes in the normal group and in the group with hypertensive disorders of pregnancy. Ultra-structurally significant changes were observed in golgi bodies, mitochondria, pinocytotic vesicles, rough endoplasmic reticulum, glycogen and interaction with pericytic processes in the endothelial cells of the placentae with hypertensive disorders of pregnancy when compared to normal placentae. CONCLUSIONS: Significant changes were observed in endothelial cells at the ultrastructural level in the placentae of women with hypertensive disorders of pregnancy.