Digital Repository

Regional Concentrations of Cyclic Nucleotides After Experimental Brain Injury

Show simple item record

dc.contributor.author Dhillon, H.S. en_US
dc.contributor.author Yang, L. en_US
dc.contributor.author Jayawardena, B.M. en_US
dc.contributor.author Dempsey, R.J. en_US
dc.contributor.author Prasad, M.R. en_US
dc.date.accessioned 2014-11-19T04:40:11Z
dc.date.available 2014-11-19T04:40:11Z
dc.date.issued 1995
dc.identifier.citation Regional concentrations of cyclic nucleotides after experimental brain injury, H.S. Dhillon, L. Yang, B.Padmaperuma, R.J.Dempsey, and M.R.Prasad, J.Neurotrauma Dec. 12 (6) 1035-43 1995.
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/3779
dc.identifier.uri http://online.liebertpub.com/doi/abs/10.1089/neu.1995.12.1035
dc.description.abstract Regional concentrations of lactate, glucose, cAMP, and cGMP were measured after lateral fluid percussion brain injury in rats. At 5 min after injury, while tissue concentrations of lactate were elevated in the cortices and hippocampi of both the ipsilateral and contralateral hemispheres, those of glucose were decreased in these brain regions. By 20 min after injury, increases of lactate concentrations and decreases of glucose concentrations were observed only in the cortices and in the hippocampus of the ipsilateral hemisphere. Whereas the cAMP concentrations were unchanged in the cortices and hippocampi of the ipsilateral and contralateral hemispheres at 5 min after injury, decreases were found in the injured cortex and ipsilateral hippocampus at 20 min after injury. The tissue concentrations of cGMP were found to be elevated only in the ipsilateral hippocampus at 5 min after injury. The present observation that tissue glucose decreases in the injured cortex and the ipsilateral hippocampus are consistent with the published findings of increased hyperglycolysis and oxidative metabolism in brain immediately after injury. The present findings that the concentrations of cAMP and cGMP change in the cortex and hippocampus provide biochemical evidence for the neurotransmitter's surge after brain injury. en_US
dc.publisher Journal of Neurotrauma en_US
dc.title Regional Concentrations of Cyclic Nucleotides After Experimental Brain Injury
dc.type article en_US
dc.identifier.department Biochemistry en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Advanced Search

Browse

My Account