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DC Field | Value | Language |
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dc.contributor.author | Senaratne, W.V. | - |
dc.contributor.author | Pinidiyapathirage, M.J. | - |
dc.contributor.author | Perera, G.A.M.H.E. | - |
dc.contributor.author | Wickremasinghe, A.R. | - |
dc.date.accessioned | 2015-09-15T10:32:14Z | - |
dc.date.available | 2015-09-15T10:32:14Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | The Ceylon Medical Journal. 2007; 52(Supplement 1):15 | en_US |
dc.identifier.issn | 0009-0875 (Print) | - |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/9571 | - |
dc.description | Oral Presentation Abstract (OP20), 120th Annual Scientific Sessions, Sri Lanka Medical Association, 2007 Colombo, Sri Lanka | en_US |
dc.description.abstract | OBJECTIVE: To determine the incidence and risk factors of anti-TB drug induced hepatitis (AIH) in Sri Lankan patients and to address management options. DESIGN, SETTING AND METHODS: 783 patients with a confirmed diagnosis of TB who presented to a unit at Chest Hospital, Welisara from April 2001 to April 2002 were recruited for a follow up study. WHO category 1 for new and category 2 for re-treatment cases was commenced using single drug formulations. Doses were based on three weight bands. AIH was diagnosed when patients complained of decreased appetite, nausea/vomiting and elevated serum biliru&n (SB) l.lmg/dl or elevated serum alanine transferase (ALT) 3 times upper limit of normal (ULN). Results: 74 patients (9.5%) out of 783 enrolled patients developed AIH; the majority (58%) developing AIH within the first two weeks of the intensive phase of treatment. AIH was commoner among patients over 60 years (p=0.018), with pulmonary TB (p=0.028) and weighing 33-35 kg (p=0.004). Using regression analysis, age, weight and rifampicin overdosage were significant predictors of AIH. Of the 74 AIH patients, standard treatment was restarted in 60 and treatment was modified in six; two defaulted and six died. Conclusions: Incidence of AIH among Sri Lankan patients is 9.5%. They develop symptoms of hepatitis when ALT levels rise to three times the ULN lowering the threshold for diagnosis of AIH. Old age, 33-55 kg weight band and rifampicin over dosage are risk factors for AIH. Majority (81%) of AIH patients could be restarted on standard treatment. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Sri Lanka Medical Association | en_US |
dc.subject | Anti-tuberculous drug | en_US |
dc.title | Anti-tuberculous drug induced hepatitis in Sri Lankan patients | en_US |
dc.type | Article | en_US |
Appears in Collections: | Conference Papers |
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