Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/9282
Title: Childhood functional abdominal pain: mechanisms and management
Authors: Korterink, J.
Devanarayana, N.M.
Rajindrajith, S.
Vlieger, A.
Benninga, M.A.
Keywords: Abdominal Pain
Issue Date: 2015
Publisher: Nature Pub. Group
Citation: Nature Reviews. Gastroenterology and Hepatology.2015;12(3):159-71
Abstract: Chronic abdominal pain is one of the most common clinical syndromes encountered in day to day clinical paediatric practice. Although common, its definition is confusing, predisposing factors are poorly understood and the pathophysiological mechanisms are not clear. The prevailing viewpoint in the pathogenesis involves the inter-relationship between changes in hypersensitivity and altered motility, to which several risk factors have been linked. Making a diagnosis of functional abdominal pain can be a challenge, as it is unclear which further diagnostic tests are necessary to exclude an organic cause. Moreover, large, well-performed, high-quality clinical trials for effective agents are lacking, which undermines evidence-based treatment. This Review summarizes current knowledge regarding the epidemiology, pathophysiology, risk factors and diagnostic work-up of functional abdominal pain. Finally, management options for children with functional abdominal pain are discussed including medications, dietary interventions, probiotics and psychological and complementary therapies, to improve understanding and to maximize the quality of care for children with this condition.
Description: Indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/9282
ISSN: 1759-5045 (Print)
1759-5053 (Electronic)
Appears in Collections:Journal/Magazine Articles

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