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Title: | Liquid gastric emptying and antral motility in adult asthmatics |
Authors: | Amarasiri, W.A.D.L. de Silva, H.J. Ranasinghe, C.P. |
Issue Date: | 2008 |
Publisher: | University of Kelaniya |
Citation: | Amarasiri, W.A.D.L., De Silva, H.J. and Ranasinghe, C., 2008. Liquid gastric emptying and antral motility in adult asthmatics, Proceedings of the Annual Research Symposium 2008, Faculty of Graduate Studies, University of Kelaniya, pp 171-172. |
Abstract: | Introduction: Asthmatics have increased prevalence of gastro-oesophageal reflux disease (GERD). Gastric antral hypomotility may contribute to this. Gastric motility has been little studied in asthma. Objective: To study gastric emptying (GE) of a liquid meal in adult asthmatics and investigate association with GERD symptoms and autonomic functions. Method: GE response to 200mL of chicken soup (54kJ, 15% protein, 30% fat and 65% carbohydrate) was assessed by real time ultrasonography in 30 stable, mild asthmatics (diagnosed according to American Thoracic Society Criteria) and 30 healthy controls. Percentage emptying at 15 minutes (GER%) and antral motility index were measured. Symptomatic GERD was assessed by a validated questionnaire, and autonomic nervous function by blood pressure and heart rate response to standing and deep breathing and the Valsalva maneuver. Results: The asthmatics (15 males, age (mean ± SD) 34.7 ± 8.4) and controls were comparable in age, gender and body mass index. On autonomic function assessment, 3 asthmatics showed hypervagal response, 2 showed reduced vagal response but none showed a hyperadrenergic response. They were only on inhaled ��-agonists as required. Although, 20 asthmatics had symptomatic GERD, none had endoscopic gastric pathology. Compared to controls, asthmatics had significantly delayed GER% (mean ± SD 55.4±14.4 versus 64.0±13.5, p=0.036) and lower antral motility index (mean ± SD 4.9±1.5 versus 6.4±1.4, p=<O.OO 1 ). There was no significant association of GE parameters with presence of GERD symptoms or autonomic function. Conclusion: Asthmatics have delayed gastric emptying and impaired antral motility, independent of GERD status or autonomic nervous function. |
URI: | http://repository.kln.ac.lk/handle/123456789/7896 |
Appears in Collections: | ARS 2008 |
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File | Description | Size | Format | |
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W.A.D.L. Amarasiri.pdf | 107.43 kB | Adobe PDF | View/Open |
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