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DC Field | Value | Language |
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dc.contributor.author | Pandithavidana D R | en_US |
dc.date.accessioned | 2014-11-19T04:40:17Z | - |
dc.date.available | 2014-11-19T04:40:17Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/3795 | - |
dc.description.abstract | The extreme cytotoxicity of natural enediyne antibiotics is attributed to the ability of the (Z)-3-ene-1,5-diyne fragment incorporated into a 10- or 9-membered ring cyclic system to undergo Bergman cyclization and producing dDNA-damaging p-benzyne diradical. The rate of this reaction strongly depends on the ring size. Thus 11-membered ring enediynes are stable, 10-membered ring analogs undergo slow cycloaromatization under ambient conditions or mild heating. Very little is known about reactivity of 9-membered ring enediynes due to their instability. We have developed thermally stable photo-precursors of 9-membered enediynes, in which one of the triple bonds is replaced by the cyclopropenone group. UV irradiation of the photo-precursor results in the efficient decarbonylation and the formation of reactive enediyne. The latter undergoes clean cycloaromatization spontaneously with absence of any chemical additives. Synthetic strategies of a series of cyclopropenone containing nine-membered enediyne precursors and DNA-cleavaging activity of the photo-generated enediynes have been also discussed. | en_US |
dc.publisher | LAP LAMBERT Academic Publishing | en_US |
dc.title | Photoswitchable Nine-Membered Cyclic Enediynes and Enyne-Allenes | - |
dc.type | article | en_US |
dc.identifier.department | Chemistry | en_US |
Appears in Collections: | Chemistry |
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