Please use this identifier to cite or link to this item:
http://repository.kln.ac.lk/handle/123456789/26770
Title: | Identification of type 2 diabetes patients with non-alcoholic fatty liver disease who are at increased risk of significant hepatic fibrosis: a cross-sectional study |
Authors: | Mettananda, K.C.D. Egodage, T. Dantanarayana, C. Solangarachchi, M.B. Fernando, R. Ranaweera, L. Siriwardhena, S. Ranawaka, C.K. Kottahachchi, D. Pathmeswaran, A. Dassanayake, A.S. de Silva, H.J. |
Keywords: | Nonalcoholic Fatty liver disease NAFLD Diabetes mellitus Significant liver fibrosis Vibration controlled transient elastography |
Issue Date: | 2023 |
Publisher: | Sri Lanka Medical Association |
Citation: | Sri Lanka Medical Association, 136th Anniversary International Medical Congress. 2023; 68 (Supplement S):S25 |
Abstract: | INTRODUCTION: Annual screening of patients with diabetes for fatty liver, and identifying those with significant hepatic fibrosis using the FIB-4 score and vibration-controlled transient elastography (VCTE) has been recommended to detect patients who may progress to advanced hepatic fibrosis/cirrhosis. However, VCTE is not freely available in resource-limited settings. OBJECTIVES: To identify clinical and biochemical predictors of significant liver fibrosis in diabetics with fatty liver. METHODS: We conducted a cross-sectional study among all consenting adults with T2DM and non-alcoholic fatty liver disease (NAFLD) attending the Colombo North Teaching Hospital, Ragama, Sri Lanka from November 2021 to November 2022. FIB-4 scores were calculated and patients with a score ≥1.3 underwent VCTE. Risk associations for liver fibrosis were identified by comparing patients with significant fibrosis (LSM ≥8 kPa) with those without significant fibrosis (FIB-4<1.3). RESULTS: A total of 363 persons were investigated. Of these, 243 had a score of FIB-4 <1.3. Of the 120 with a FIB-4 ≥1.3, 76 had LSM ≥8 kPa. Significant fibrosis was individually associated with age (OR 1.01, p<0.0001), duration of diabetes (OR 1.02, p=0.006), family history of liver disease (OR 1.42, p=0.035), waist (OR 1.04, p=0.035), and FIB-4 (OR 2.08, p<0.0001). However, on adjusted analysis, significant fibrosis was only associated with a family history of liver disease (OR 2.69, p=0.044) and FIB-4 (OR 1.43, p<0.001). CONCLUSION: In patients with T2DM and fatty liver, advancing age, increased duration of diabetes, a family history of liver disease, waist circumference and a high FIB-4 score increase the risk of significant hepatic fibrosis. Targeted interventions in this group may help prevent progression to advanced hepatic fibrosis/cirrhosis. |
Description: | Oral Presentation Abstract (OP 023), 136th Anniversary International Medical Congress, Sri Lanka Medical Association, 25th-28th July 2023, Colombo, Sri Lanka |
URI: | http://repository.kln.ac.lk/handle/123456789/26770 |
ISSN: | 0009-0875 |
Appears in Collections: | Conference Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Abstract-book-2023-FINAL-VERSION-2.0-25.pdf | 519.38 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.