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dc.contributor.author | Mahajan, A. | |
dc.contributor.author | Spracklen, C.N. | |
dc.contributor.author | Zhang, W. | |
dc.contributor.author | Ng, M.C.Y. | |
dc.contributor.author | Petty, L.E. | |
dc.contributor.author | Kitajima, H. | |
dc.contributor.author | Yu, G.Z. | |
dc.contributor.author | Rüeger, S. | |
dc.contributor.author | Speidel, L. | |
dc.contributor.author | Kim, Y.J. | |
dc.contributor.author | Horikoshi, M. | |
dc.contributor.author | Mercader, J.M . | |
dc.contributor.author | Taliun, D. | |
dc.contributor.author | Moon, S. | |
dc.contributor.author | Kwak, S.H. | |
dc.contributor.author | Robertson, N.R. | |
dc.contributor.author | Rayner, N.W. | |
dc.contributor.author | Loh, M. | |
dc.contributor.author | Kim, B. | |
dc.contributor.author | Chiou, J. | |
dc.contributor.author | Miguel-Escalada, I. | |
dc.contributor.author | Parolo, P.D.B. | |
dc.contributor.author | Lin, K. | |
dc.contributor.author | Bragg, F. | |
dc.contributor.author | Preuss, M.H. | |
dc.contributor.author | Takeuchi, F. | |
dc.contributor.author | Nano, J. | |
dc.contributor.author | Guo, X. | |
dc.contributor.author | Lamri, A. | |
dc.contributor.author | Nakatoch, M. | |
dc.contributor.author | Scott, R.A. | |
dc.contributor.author | Lee, J.J. | |
dc.contributor.author | Huerta-Chagoya, A. | |
dc.contributor.author | Graff, M. | |
dc.contributor.author | Chai, J.F. | |
dc.contributor.author | Parra, E. J. | |
dc.contributor.author | Yao, J. | |
dc.contributor.author | Bielak, L.F. | |
dc.contributor.author | Tabara, Y. | |
dc.contributor.author | Hai, Y. | |
dc.contributor.author | Steinthorsdottir, V. | |
dc.contributor.author | Cook, J.P. | |
dc.contributor.author | Kals, M. | |
dc.contributor.author | Grarup, N. | |
dc.contributor.author | Schmidt, E.M. | |
dc.contributor.author | Pan, I. | |
dc.contributor.author | Sofer, T. | |
dc.contributor.author | Wuttke, M. | |
dc.contributor.author | Sarnowski, C. | |
dc.contributor.author | Gieger, C. | |
dc.contributor.author | Nousome, D. | |
dc.contributor.author | Trompet, S. | |
dc.contributor.author | Long, J. | |
dc.contributor.author | Sun, M. | |
dc.contributor.author | Tong, L. | |
dc.contributor.author | Chen, W.M. | |
dc.contributor.author | Ahmad, M. | |
dc.contributor.author | Noordam, R. | |
dc.contributor.author | Lim, V.J.Y. | |
dc.contributor.author | Tam, C.H.T. | |
dc.contributor.author | Joo, Y.Y. | |
dc.contributor.author | Chen, C.H. | |
dc.contributor.author | Raffield, L.M. | |
dc.contributor.author | Lecoeur, C. | |
dc.contributor.author | Prins, B.P. | |
dc.contributor.author | Nicolas, A. | |
dc.contributor.author | Yanek, L.R. | |
dc.contributor.author | Chen, G. | |
dc.contributor.author | Jensen, R.A. | |
dc.contributor.author | Tajuddin, S. | |
dc.contributor.author | Kabagambe, E.K. | |
dc.contributor.author | An, P. | |
dc.contributor.author | Xiang, A.H. | |
dc.contributor.author | Choi, H.S. | |
dc.contributor.author | Cade, B.E. | |
dc.contributor.author | Tan, J. | |
dc.contributor.author | Flanagan, J. | |
dc.contributor.author | Abaitua, F. | |
dc.contributor.author | Adair, L.S. | |
dc.contributor.author | Adeyemo, A. | |
dc.contributor.author | Aguilar-Salinas, C.A. | |
dc.contributor.author | Akiyama, M. | |
dc.contributor.author | Anand, S.S. | |
dc.contributor.author | Bertoni, A. | |
dc.contributor.author | Bian, Z. | |
dc.contributor.author | Bork-Jensen, J. | |
dc.contributor.author | Brandslund, I. | |
dc.contributor.author | Brody, J.A. | |
dc.contributor.author | Brummett, C.M. | |
dc.contributor.author | Buchanan, T.A. | |
dc.contributor.author | Canouil, M. | |
dc.contributor.author | Chan, J.C.N. | |
dc.contributor.author | Chang, L.C. | |
dc.contributor.author | Chee, M.L. | |
dc.contributor.author | Chen, J. | |
dc.contributor.author | Chen, S.H. | |
dc.contributor.author | Chen, Y.T. | |
dc.contributor.author | Chen, Z. | |
dc.contributor.author | Chuang, L.M. | |
dc.contributor.author | Cushman, M. | |
dc.contributor.author | Das, S.K. | |
dc.contributor.author | de Silva, H.J. | |
dc.contributor.author | Dedoussis, G. | |
dc.contributor.author | Dimitrov, L. | |
dc.contributor.author | Doumatey, A.P. | |
dc.contributor.author | Du, S. | |
dc.contributor.author | Duan, Q. | |
dc.contributor.author | Eckardt, K.U. | |
dc.contributor.author | Emery, L.S. | |
dc.contributor.author | Evans, D.S. | |
dc.contributor.author | Evans, M.K. | |
dc.contributor.author | Fischer, K. | |
dc.contributor.author | Floyd, J.S. | |
dc.contributor.author | Ford, I. | |
dc.contributor.author | Fornage, M. | |
dc.contributor.author | Franco, O.H. | |
dc.contributor.author | Frayling, T.M. | |
dc.contributor.author | Freedman, B.I. | |
dc.contributor.author | Fuchsberger, C. | |
dc.contributor.author | Genter, P. | |
dc.contributor.author | Gerstein, H.C. | |
dc.contributor.author | Giedraitis, V. | |
dc.contributor.author | Villalpando, C.G. | |
dc.contributor.author | Villalpando, M.E.G. | |
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dc.contributor.author | Huang, M. | |
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dc.contributor.author | Hwu, C. | |
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dc.contributor.author | Jang, H.M. | |
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dc.contributor.author | Jiang, G. | |
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dc.contributor.author | Jørgensen, M.E. | |
dc.contributor.author | Jørgensen, T. | |
dc.contributor.author | Kamatani, Y. | |
dc.contributor.author | Kandeel, F.R. | |
dc.contributor.author | Kasturiratne, A. | |
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dc.contributor.author | Kaur, V. | |
dc.contributor.author | Kawaguchi, T. | |
dc.contributor.author | Keaton, J.M. | |
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dc.contributor.author | Kibriya, M.G. | |
dc.contributor.author | Kim, D.H. | |
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dc.contributor.author | Kriebel, J. | |
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dc.contributor.author | Liu, S. | |
dc.contributor.author | Abecasis, G. | |
dc.contributor.author | Kooner, J.S. | |
dc.contributor.author | Loos, R.J.F. | |
dc.contributor.author | North, K.E. | |
dc.contributor.author | Haiman, C.A. | |
dc.contributor.author | Florez, J.C. | |
dc.contributor.author | Saleheen, D. | |
dc.contributor.author | Hansen, T. | |
dc.contributor.author | Pedersen, O. | |
dc.contributor.author | Mägi, R. | |
dc.contributor.author | Langenberg, C. | |
dc.contributor.author | Wareham, N.J. | |
dc.contributor.author | Maeda, S. | |
dc.contributor.author | Kadowaki, T. | |
dc.contributor.author | Lee, J. | |
dc.contributor.author | Millwood, I.Y. | |
dc.contributor.author | Walters, R.G. | |
dc.contributor.author | Stefansson, K. | |
dc.contributor.author | Myers, S.R. | |
dc.contributor.author | Ferrer, J. | |
dc.contributor.author | Gaulton, K.J. | |
dc.contributor.author | Meigs, J.B. | |
dc.contributor.author | Mohlke, K.L. | |
dc.contributor.author | Gloyn, A.L. | |
dc.contributor.author | Bowden, D.W. | |
dc.contributor.author | Below, J.E. | |
dc.contributor.author | Chambers, J.C. | |
dc.contributor.author | Sim, X. | |
dc.contributor.author | Boehnke, M. | |
dc.contributor.author | Rotter, J.I. | |
dc.contributor.author | McCarthy, M.I. | |
dc.contributor.author | Morris, A.P. | |
dc.date.accessioned | 2022-06-03T06:15:47Z | |
dc.date.available | 2022-06-03T06:15:47Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Nature Genetics.2022;54(5):560-572. | en_US |
dc.identifier.issn | 1061-4036 | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/24629 | |
dc.description | Indexed in MEDLINE. | en_US |
dc.description.abstract | We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10-9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Company, New York | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Populations | en_US |
dc.title | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
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