Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/24582
Title: Postinfectious Acute Cerebellar Syndromes in children: A nationally ascertained case series from Australia 2013-2018
Authors: Gunaratna, G.P.S.
Mohammad, S.S.
Blyth, C.C.
Clark, J.
Crawford, N.
Marshall, H.
Dale, R.C.
Jones, C.A.
Britton, P.N.
PAEDS Network
Keywords: acute cerebellar syndromes
post/para infections
varicella
varicella vaccination
Issue Date: 2022
Publisher: Littleton
Citation: Journal of Child Neurology. 2022;37(7); 617-623. [Epub 2022 May12]
Abstract: Introduction: Postinfectious acute cerebellar syndromes show a wide spectrum of acute severity and can occur with acute febrile illness or vaccine receipt. Varicella has historically been the most common cause, associated with up to 25% of cases in large cohorts. This study aimed to describe the spectrum of syndromes in a setting with high varicella vaccine coverage. Method: Data were collected on children initially identified as "suspected encephalitis" subsequently designated "not-encephalitis" at participating children's hospitals in the Paediatric Active Enhanced Disease Surveillance (PAEDS) network, Australia, as part of the Acute Childhood Encephalitis study. A comprehensive descriptive analysis was undertaken on prospectively identified, national series of children with postinfectious acute cerebellar syndromes from 2013 to 2018. Cases were classified using a previously validated severity score, and the outcome was assessed at 12 months using the Liverpool Outcome Scale score. Results: A total of 20 cases (65% were vaccinated for varicella) were included, of which 70% were subcategorized as acute cerebellar ataxia (ACA), 20% acute cerebellitis (AC), and 10% acute fulminant cerebellitis (AFC). An acute febrile illness was noted in 55% and none were related to varicella or were temporally related to varicella vaccination or other childhood vaccines. A subset (total of 7 children) followed up at 12 months all showed reduced Liverpool Outcome Scale scores. Discussion: The study provides an overall description of this uncommon spectrum of neurologic syndromes and shows the infrequency of varicella zoster virus as a cause in a vaccinated population.
Description: Indexed in MEDLINE.
URI: http://repository.kln.ac.lk/handle/123456789/24582
ISSN: 0883-0738
Appears in Collections:Journal/Magazine Articles

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