Please use this identifier to cite or link to this item:
http://repository.kln.ac.lk/handle/123456789/24343
Title: | Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: analysis of survival and prognostic markers |
Authors: | Chan, K.K. Dassanayake, B. Deen, R. Wickramarachchi, R.E. Kumarage, S.K. Samita, S. Deen, K.I. |
Keywords: | Colorectal Neoplasms Colorectal Neoplasms-diagnosis Colorectal Neoplasms-surgery Colorectal Neoplasms-mortality Colectomy Neoplasm Staging-methods Postoperative Period Follow-Up Studies Prospective Studies Sri Lanka-epidemiology Risk Factors Survival Rate-trends |
Issue Date: | 2010 |
Publisher: | BioMed Central |
Citation: | World Journal of Surgical Oncology. 2010; 8:82 |
Abstract: | OBJECTIVES: This study compares clinico-pathological features in young (<40 years) and older patients (>50 years) with colorectal cancer, survival in the young and the influence of pre-operative clinical and histological factors on survival. MATERIALS AND METHODS: A twelve-year prospective database of colorectal cancer was analysed. Fifty-three young patients were compared with forty-seven consecutive older patients over fifty years old. An analysis of survival was undertaken in young patients using Kaplan Meier graphs, non-parametric methods, Cox's Proportional Hazard Ratios and Weibull Hazard models. RESULTS: Young patients comprised 13.4 percent of 397 with colorectal cancer. Duration of symptoms and presentation in the young was similar to older patients (median, range; young patients; 6 months, 2 weeks to 2 years, older patients; 4 months, 4 weeks to 3 years, p > 0.05). In both groups, the majority presented without bowel obstruction (young--81%, older--94%). Cancer proximal to the splenic flexure was present more in young than in older patients. Synchronous cancers were found exclusively in the young. Mucinous tumours were seen in 16% of young and 4% of older patients (p < 0.05). Ninety-four percent of young cancer deaths were within 20 months of operation. At median follow up of 50 months in the young, overall survival was 70% and disease free survival 66%. American Joint Committee on Cancer (AJCC) stage 4 and use of pre-operative chemoradiation in rectal cancer was associated with poor survival in the young. CONCLUSION: If patients, who are less than 40 years old with colorectal cancer, survive twenty months after operation, the prognosis improves and their survival becomes predictable. |
Description: | Indexed in MEDLINE; Scopus |
URI: | http://repository.kln.ac.lk/handle/123456789/24343 |
ISSN: | 1477-7819 (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
World JSurOnco-2010-8-82.pdf | 832 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.