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Title: | Oxidative stress and antioxidant deficiency in the β-thalassaemia in Sri Lanka |
Authors: | Perera, S. Allen, A. Mettananda, S. Rodrigo, R. Perera, L. Darshana, T. Moggach, F. Jackson-Crawford, A. Heirene, L. Fisher, C. Olivieri, N. Rees, D. Allen, S. Premawardhena, A. |
Keywords: | β thalassaemias |
Issue Date: | 2021 |
Publisher: | Sri Lanka Medical Association |
Citation: | Sri Lanka Medical Association, 134th Anniversary International Medical Congress. 2021;162-163 |
Abstract: | Introduction In the β thalassaemias oxidative stress is potentially high and this could be further exacerbated in the absence of robust antioxidant defences, such as nutritional vitamin C and E deficiencies. We undertook a comprehensive assessment of oxidant, antioxidant and inflammatory status in patients with subtypes of β-thalassaemia to study these factors in detail. Methods Consenting patients attending the thalassaemia centre in Ragama, (between November 2017 and June 2018) were assessed for the following: methaemoglobin, plasma haemoglobin, heme and ferritin as sources of oxidants, plasma haptoglobin, hemopexin and vitamins C and E as markers of antioxidants, plasma interleukin-6 and C-reactive protein for inflammation. Fruit and vegetable intake was determined by dietary recall. Results 162 patients were recruited. (59 HbE β-thalassaemia, 50 β-thalassaemia major, 40 β-thalassaemia intermedia, 13 HbS β-thalassaemia. Median age was 26.0 years (IQR 15.3-38.8), 101 (62.3%) were female. Oxidants were frequently increased and antioxidants depleted with high levels of oxidant damage, hypoxia and inflammation. Abnormalities were most severe in HbE-β thalassaemia and least severe in β thalassaemia intermedia. Oxidative stress was also more severe in splenectomised patients. Plasma vitamin C concentration was below the lower level of quantitation in 86/160 (53.8%) patients and vitamin E in 130/160 (81.3%) patients. Less than 15% of patients ate fresh fruits or raw vegetables frequently. Conclusion Markedly increased oxidative stress and antioxidant deficiency were observed in this study group, especially in those with HbE β-thalassaemia. Vitamin C & E supplementation may have a role in the long-term management of thalassaemia syndromes. |
Description: | Poster Presentation Abstract(PP103), “Professional Excellence Towards Holistic Healthcare”, 134th Anniversary International Medical Congress, Sri Lanka Medical Association, 21st – 24th September 2021, Colombo, Sri Lanka |
URI: | http://repository.kln.ac.lk/handle/123456789/23896 |
Appears in Collections: | Conference Papers |
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