Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/2361
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dc.contributor.authorNishad, A.A.N.en_US
dc.contributor.authorde Silva, I.S.en_US
dc.contributor.authorPerera, H.L.en_US
dc.contributor.authorPathmeswaran, A.en_US
dc.contributor.authorKasturiratne, K.T.A.A.en_US
dc.contributor.authorPremawardhena, A.P.en_US
dc.date.accessioned2014-10-29T10:14:37Z
dc.date.available2014-10-29T10:14:37Z
dc.date.issued2014en_US
dc.identifier.citationJournal of Pediatric Hematology Oncology.2014; 36(8): e490-2.en_US
dc.identifier.issn1077-4114 (Print)en_US
dc.identifier.issn1536-3678 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/2361
dc.description.abstractThe national screening policy for hemoglobinopathies uses the cutoffs for red cell indices mean corpuscular volume >80 and mean corpuscular hemoglobin >27, a strategy known to miss some individuals with Hb E trait (EBT), the most common abnormal hemoglobin in Sri Lanka. We wanted to determine if red cell distribution width (RDW) cutoff values would help in increasing the sensitivity of screening for Hb E trait. High-performance liquid chromatography was carried out as the gold standard to detect hemoglobinopathies and red blood cell parameters with colter counter. Receiver operating characteristic curve was drawn to determine the cutoff value for EBT against β-trait (BTT) and other anemias. Of the 504 patients, 246 had BTT, 110 had EBT, and 151 had other types of anemias. Mean (SD) RDW among patients with BTT was 16 (2.8), with EBT 14.5 (2.9), and with other anemias 15.8 (4.2) (P>0.001). With 14.45 as the cutoff for RDW and considering accepted values for mean corpuscular volume >80 and mean corpuscular hemoglobin >27, it gave a predictive sensitivity of 98.2% for EBT. By using RDW cutoff at 14.45 in addition to the accepted screening indices, sensitivity of Hb E trait detection went up to 98.2% from 86.6%. This study highlights the importance of taking RDW into consideration for screening
dc.publisherLippincott Williams and Wilkinsen_US
dc.titleRole of red cell distribution width in screening for Hb Etrait in population ccreening for hemoglobin disordersen_US
dc.typeArticleen_US
dc.identifier.departmentPublic Healthen_US
dc.identifier.departmentMedicineen_US
dc.creator.corporateauthorAmerican Society of Pediatric Hematology/Oncologyen_US
dc.description.noteIndexed in MEDLINEen_US
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