Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/23122
Title: Presence of fatty liver disease leads to unusual rise of liver enzymes in patients with common bile duct colic
Authors: Uragoda, B.
Ediriweera, D.
Paranahewa, L.
Ekanayake, C.
Tillakarathna, S.
Siriwardana, R.
Keywords: Fatty Liver
Cholelithiasis
Cholestasis, Intrahepatic
Enzymes
Issue Date: 2021
Publisher: Korean Association of Hepato-Biliary-Pancreatic Surgery
Citation: Annals of Hepato-Biliary-Pancreatic Surgery. 2021;25 Suppl 1:S334
Abstract: INTRODUCTION: This study compares liver enzymes, inflammatory markers and bilirubin levels in patients with and without fatty liver disease (FLD) presenting with common bile duct (CBD) obstruction. METHODS: CBD colic was diagnosed based on clinical, radiological and biochemical criterion. Presence of FLD was diagnosed by ultra sound scan and the macroscopic appearance of liver during surgery. Liver enzymes, inflammatory markers and bilirubin levels were prospectively assessed and compared between the two groups. RESULTS: Out of 42, there were 22 (52.3%) patients with FLD. Median body mass index was 26.9 (24.1–30.8) in fatty liver group compared to 25.7 (23.5–26.2) in others. Individuals with FLD showed high aspartate transaminase (558.5 vs. 247.0, p = 0.005), alanine trasaminase (467 vs. 228.5, p = 0.005) and bilirubin (3.8 vs. 2.2, p = 0.015) levels compared to those without FLD. According to multiple linear regression models, high AST and ALT levels showed significant associations with FLD after adjusting for age, gender, body mass index, amylase and C reactive protein levels. The median enzyme level at two weeks did not show a difference among patients with and without FLD. CONCLUSIONS:Presence of FLD causes unusual rise of AST and ALT levels in patients with CBD stones. This rise is transient.
Description: E Poster Presentation Abstract (EP-136), 54th Annual Congress of the Korean Association of HBP Surgery & HBP Surgery Week 2021, 25–27 March 2021, Seoul, South Korea
URI: http://repository.kln.ac.lk/handle/123456789/23122
ISSN: 1738-6349(print)
2288-9213(Electronic)
Appears in Collections:Conference Papers

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