Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/23045
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChen, J.
dc.contributor.authorSpracklen, C.N.
dc.contributor.authorMarenne, G.
dc.contributor.authorVarshney, A.
dc.contributor.authorCorbin, L.J.
dc.contributor.authorLuan, J.
dc.contributor.authorWillems, S.M.
dc.contributor.authorWu, Y.
dc.contributor.authorZhang, X.
dc.contributor.authorHorikoshi, M.
dc.contributor.authorBoutin, T.S.
dc.contributor.authorMägi, R.
dc.contributor.authorWaage, J.
dc.contributor.authorLi-Gao, R.
dc.contributor.authorChan, K.H.K
dc.contributor.authorYao, J.
dc.contributor.authorAnasanti, M.D.
dc.contributor.authorChu, A.Y.
dc.contributor.authorClaringbould, A.
dc.contributor.authorHeikkinen, J.
dc.contributor.authorHong, J.
dc.contributor.authorHottenga, J.J.
dc.contributor.authorHuo, S.
dc.contributor.authorKaakinen, M.A.
dc.contributor.authorLouie, T.
dc.contributor.authorMärz, W.
dc.contributor.authorMoreno-Macias, H.
dc.contributor.authorNdungu, A.
dc.contributor.authorNelson, S.C.
dc.contributor.authorNolte, I.M.
dc.contributor.authorNorth, K.E.
dc.contributor.authorRaulerson, C.K.
dc.contributor.authorRay, D.
dc.contributor.authorRohde, R.
dc.contributor.authorRybin, D.
dc.contributor.authorSchurmann, C.
dc.contributor.authorSim, X.
dc.contributor.authorSoutham, L.
dc.contributor.authorStewart, I.D.
dc.contributor.authorWang, C.A.
dc.contributor.authorWang, Y.
dc.contributor.authorWu, P.
dc.contributor.authorZhang, W.
dc.contributor.authorAhluwalia, T.S.
dc.contributor.authorAppel, E.V.R.
dc.contributor.authorBielak, L.F.
dc.contributor.authorBrody, J.A.
dc.contributor.authorBurtt, N.P.
dc.contributor.authorCabrera, C.P.
dc.contributor.authorCade, B.E.
dc.contributor.authorChai, J.F.
dc.contributor.authorChai, X.
dc.contributor.authorChang, L.C.
dc.contributor.authorChen, C.H.
dc.contributor.authorChen, B.H.
dc.contributor.authorChitrala, K.N.
dc.contributor.authorChiu, Y.F.
dc.contributor.authorDe Haan, H.G.
dc.contributor.authorDelgado, G.E.
dc.contributor.authorDemirkan, A.
dc.contributor.authorDuan, Q.
dc.contributor.authorEngmann, J.
dc.contributor.authorFatumo, S.A.
dc.contributor.authorGayán, J.
dc.contributor.authorGiulianini, F.
dc.contributor.authorGong, J.H.
dc.contributor.authorGustafsson, S.
dc.contributor.authorHai, Y.
dc.contributor.authorHartwig, F.P.
dc.contributor.authorHe, J.
dc.contributor.authorHeianza, Y.
dc.contributor.authorHuang, T.
dc.contributor.authorHuerta-Chagoya, A.
dc.contributor.authorHwang, M.Y.
dc.contributor.authorJensen, R.A.
dc.contributor.authorKawaguchi, T.
dc.contributor.authorKentistou, K.A.
dc.contributor.authorKim, Y.J.
dc.contributor.authorKleber, M.E.
dc.contributor.authorKooner, I.K.
dc.contributor.authorLai, S.
dc.contributor.authorLange, L.A.
dc.contributor.authorLangefeld, C.D.
dc.contributor.authorLauzon, M.
dc.contributor.authorLi, M.
dc.contributor.authorLigthart, S.
dc.contributor.authorLiu, J.
dc.contributor.authorLoh, M.
dc.contributor.authorLong, J.
dc.contributor.authorLyssenko, V.
dc.contributor.authorMangino, M.
dc.contributor.authorMarzi, C.
dc.contributor.authorMontasser, M.E.
dc.contributor.authorNag, A.
dc.contributor.authorNakatochi, M.
dc.contributor.authorNoce, D.
dc.contributor.authorNoordam, R.
dc.contributor.authorPistis, G.
dc.contributor.authorPreuss, M.
dc.contributor.authorRaffield, L.
dc.contributor.authorRasmussen-Torvik, L.J.
dc.contributor.authorRich, S.S.
dc.contributor.authorRobertson, N.R.
dc.contributor.authorRueedi, R.
dc.contributor.authorRyan, K.
dc.contributor.authorSanna, S.
dc.contributor.authorSaxena, R.
dc.contributor.authorSchraut, K.E.
dc.contributor.authorSennblad, B.
dc.contributor.authorSetoh, K.
dc.contributor.authorSmith, A.V.
dc.contributor.authorSparsø, T.
dc.contributor.authorStrawbridge, R.J.
dc.contributor.authorTakeuchi, F.
dc.contributor.authorTan, J.
dc.contributor.authorTrompet, S.
dc.contributor.authorVan den Akker, E.
dc.contributor.authorVan der Most, P.J.
dc.contributor.authorVerweij, N.
dc.contributor.authorVogel, M.
dc.contributor.authorWang, H.
dc.contributor.authorWang, C.
dc.contributor.authorWang, N.
dc.contributor.authorWarren, H.R.
dc.contributor.authorWen, W.
dc.contributor.authorWilsgaard, T.
dc.contributor.authorWong, A.
dc.contributor.authorWood, A.R.
dc.contributor.authorXie, T.
dc.contributor.authorZafarmand, M.H.
dc.contributor.authorZhao, J.H.
dc.contributor.authorZhao, W.
dc.contributor.authorAmin, N.
dc.contributor.authorArzumanyan, Z.
dc.contributor.authorAstrup, A.
dc.contributor.authorBakker, S.J.L.
dc.contributor.authorBaldassarre, D.
dc.contributor.authorBeekman, M.
dc.contributor.authorBergman, R.N.
dc.contributor.authorBertoni, A.
dc.contributor.authorBlüher, M.
dc.contributor.authorBonnycastle, L.L.
dc.contributor.authorBornstein, S.R.
dc.contributor.authorBowden, D.W.
dc.contributor.authorCai, Q.
dc.contributor.authorCampbell, A.
dc.contributor.authorCampbell, H.
dc.contributor.authorChang, Y.C.
dc.contributor.authorde Geus, E.J.C.
dc.contributor.authorDehghan, A.
dc.contributor.authorDu, S.
dc.contributor.authorEiriksdottir, G.
dc.contributor.authorFarmaki, A.E.
dc.contributor.authorFrånberg, M.
dc.contributor.authorFuchsberger, C.
dc.contributor.authorGao, Y.
dc.contributor.authorGjesing, A.P.
dc.contributor.authorGoel, A.
dc.contributor.authorHan, S.
dc.contributor.authorHartman, C.A.
dc.contributor.authorHerder, C.
dc.contributor.authorHicks, A.A.
dc.contributor.authorHsieh, C.H.
dc.contributor.authorHsueh, W.A.
dc.contributor.authorIchihara, S.
dc.contributor.authorIgase, M.
dc.contributor.authorIkram, M.A.
dc.contributor.authorJohnson, W.C.
dc.contributor.authorJørgensen, M.E.
dc.contributor.authorJoshi, P.K.
dc.contributor.authorKalyani, R.R.
dc.contributor.authorKandeel, F.R.
dc.contributor.authorKatsuya, T.
dc.contributor.authorKhor, C.C.
dc.contributor.authorKiess, W.
dc.contributor.authorKolcic, I.
dc.contributor.authorKuulasmaa, T.
dc.contributor.authorKuusisto, J.
dc.contributor.authorLäll, K.
dc.contributor.authorLam, K.
dc.contributor.authorLawlor, D.A.
dc.contributor.authorLee, N.R.
dc.contributor.authorLemaitre, R.N.
dc.contributor.authorLi, H.
dc.contributor.authorLifelines Cohort Study
dc.contributor.authorLin, S.Y.
dc.contributor.authorLindström, J.
dc.contributor.authorLinneberg, A.
dc.contributor.authorLiu, J.
dc.contributor.authorLorenzo, C.
dc.contributor.authorMatsubara, T.
dc.contributor.authorMatsuda, F.
dc.contributor.authorMingrone, G.
dc.contributor.authorMooijaart, S.
dc.contributor.authorMoon, S.
dc.contributor.authorNabika, T.
dc.contributor.authorNadkarni, G.N.
dc.contributor.authorNadler, J.L.
dc.contributor.authorNelis, M.
dc.contributor.authorNeville, M.J.
dc.contributor.authorNorris, J.M.
dc.contributor.authorOhyagi, Y.
dc.contributor.authorPeters, A.
dc.contributor.authorPeyser, P.A.
dc.contributor.authorPolasek, O.
dc.contributor.authorQi, Q.
dc.contributor.authorRaven, D.
dc.contributor.authorReilly, D.F.
dc.contributor.authorReiner, A.
dc.contributor.authorRivideneira, F.
dc.contributor.authorRoll, K.
dc.contributor.authorRudan, I.
dc.contributor.authorSabanayagam, C.
dc.contributor.authorSandow, K.
dc.contributor.authorSattar, N.
dc.contributor.authorSchürmann, A.
dc.contributor.authorShi, J.
dc.contributor.authorStringham, H.M.
dc.contributor.authorTaylor, K.D.
dc.contributor.authorTeslovich, T.M.
dc.contributor.authorThuesen, B.
dc.contributor.authorTimmers, P.R.H.J.
dc.contributor.authorTremoli, E.
dc.contributor.authorTsai, M.Y.
dc.contributor.authorUitterlinden, A.
dc.contributor.authorvan Dam, R.M.
dc.contributor.authorvan Heemst, D.
dc.contributor.authorvan Hylckama Vlieg, A.
dc.contributor.authorvan Vliet-Ostaptchouk, J.V.
dc.contributor.authorVangipurapu, J.
dc.contributor.authorVestergaard, H.
dc.contributor.authorWang, T.
dc.contributor.authorWillems van Dijk, K.
dc.contributor.authorZemunik, T.
dc.contributor.authorAbecasis, G.R.
dc.contributor.authorAdair, L.S.
dc.contributor.authorAguilar-Salinas, C.A.
dc.contributor.authorAlarcón-Riquelme, M.E.
dc.contributor.authorAn, P.
dc.contributor.authorAviles-Santa, L.
dc.contributor.authorBecker, D.M.
dc.contributor.authorBeilin, L.J.
dc.contributor.authorBergmann, S.
dc.contributor.authorBisgaard, H.
dc.contributor.authorBlack, C.
dc.contributor.authorBoehnke, M.
dc.contributor.authorBoerwinkle, E.
dc.contributor.authorBöhm, B.O.
dc.contributor.authorBønnelykke, K.
dc.contributor.authorBoomsma, D.I.
dc.contributor.authorBottinger, E.P.
dc.contributor.authorBuchanan, T.A.
dc.contributor.authorCanouil, M.
dc.contributor.authorCaulfield, M.J.
dc.contributor.authorChambers, J.C.
dc.contributor.authorChasman, D.I.
dc.contributor.authorChen, Y.I.
dc.contributor.authorCheng, C.Y.
dc.contributor.authorCollins, F.S.
dc.contributor.authorCorrea, A.
dc.contributor.authorCucca, F.
dc.contributor.authorde Silva, H.J.
dc.contributor.authorDedoussis, G.
dc.contributor.authorElmståhl, S.
dc.contributor.authorEvans, M.K.
dc.contributor.authorFerrannini, E.
dc.contributor.authorFerrucci, L.
dc.contributor.authorFlorez, J.C.
dc.contributor.authorFranks, P.W.
dc.contributor.authorFrayling, T.M.
dc.contributor.authorFroguel, P.
dc.contributor.authorGigante, B.
dc.contributor.authorGoodarzi, M.O.
dc.contributor.authorGordon-Larsen, P.
dc.contributor.authorGrallert, H.
dc.contributor.authorGrarup, N.
dc.contributor.authorGrimsgaard, S.
dc.contributor.authorGroop, L.
dc.contributor.authorGudnason, V.
dc.contributor.authorGuo, X.
dc.contributor.authorHamsten, A.
dc.contributor.authorHansen, T.
dc.contributor.authorHayward, C.
dc.contributor.authorHeckbert, S.R.
dc.contributor.authorHorta, B.L.
dc.contributor.authorHuang, W.
dc.contributor.authorIngelsson, E.
dc.contributor.authorJames, P.S.
dc.contributor.authorJarvelin, M.R.
dc.contributor.authorJonas, J.B.
dc.contributor.authorJukema, J.W.
dc.contributor.authorKaleebu, P.
dc.contributor.authorKaplan, R.
dc.contributor.authorKardia, S.L.R.
dc.contributor.authorKato, N.
dc.contributor.authorKeinanen-Kiukaanniemi, S.M.
dc.contributor.authorKim, B.J.
dc.contributor.authorKivimaki, M.
dc.contributor.authorKoistinen, H.A.
dc.contributor.authorKooner, J.S.
dc.contributor.authorKörner, A.
dc.contributor.authorKovacs, P.
dc.contributor.authorKuh, D.
dc.contributor.authorKumari, M.
dc.contributor.authorKutalik, Z.
dc.contributor.authorLaakso, M.
dc.contributor.authorLakka, T.A.
dc.contributor.authorLauner, L.J.
dc.contributor.authorLeander, K.
dc.contributor.authorLi, H.
dc.contributor.authorLin, X.
dc.contributor.authorLind, L.
dc.contributor.authorLindgren, C.
dc.contributor.authorLiu, S.
dc.contributor.authorLoos, R.J.F.
dc.contributor.authorMagnusson, P.K.E.
dc.contributor.authorMahajan, A.
dc.contributor.authorMetspalu, A.
dc.contributor.authorMook-Kanamori, D.O.
dc.contributor.authorMori, T.A.
dc.contributor.authorMunroe, P.B.
dc.contributor.authorNjølstad, I.
dc.contributor.authorO'Connell, J.R.
dc.contributor.authorOldehinkel, A.J.
dc.contributor.authorOng, K.K.
dc.contributor.authorPadmanabhan, S.
dc.contributor.authorPalmer, C.N.A.
dc.contributor.authorPalmer, N.D.
dc.contributor.authorPedersen, O.
dc.contributor.authorPennell, C.E.
dc.contributor.authorPorteous, D.J.
dc.contributor.authorPramstaller, P.P.
dc.contributor.authorProvince, M.A.
dc.contributor.authorPsaty, B.M.
dc.contributor.authorQi, L.
dc.contributor.authorRaffel, L.J.
dc.contributor.authorRauramaa, R.
dc.contributor.authorRedline, S.
dc.contributor.authorRidker, P.M.
dc.contributor.authorRosendaal, F.R.
dc.contributor.authorSaaristo, T.E.
dc.contributor.authorSandhu, M.
dc.contributor.authorSaramies, J.
dc.contributor.authorSchneiderman, N.
dc.contributor.authorSchwarz, P.
dc.contributor.authorScott, L.J.
dc.contributor.authorSelvin, E.
dc.contributor.authorSever, P.
dc.contributor.authorShu, X.O.
dc.contributor.authorSlagboom, P.E.
dc.contributor.authorSmall, K.S.
dc.contributor.authorSmith, B.H.
dc.contributor.authorSnieder, H.
dc.contributor.authorSofer, T.
dc.contributor.authorSørensen, T.I.A.
dc.contributor.authorSpector, T.D.
dc.contributor.authorStanton, A.
dc.contributor.authorSteves, C.J.
dc.contributor.authorStumvoll, M.
dc.contributor.authorSun, L.
dc.contributor.authorTabara, Y.
dc.contributor.authorTai, E.S.
dc.contributor.authorTimpson, N.J.
dc.contributor.authorTönjes, A.
dc.contributor.authorTuomilehto, J.
dc.contributor.authorTusie, T.
dc.contributor.authorUusitupa, M.
dc.contributor.authorvan der Harst, P.
dc.contributor.authorvan Duijn, C.
dc.contributor.authorVitart, V.
dc.contributor.authorVollenweider, P.
dc.contributor.authorVrijkotte, T.G.M.
dc.contributor.authorWagenknecht, L.E.
dc.contributor.authorWalker, M.
dc.contributor.authorWang, Y.X.
dc.contributor.authorWareham, N.J.
dc.contributor.authorWatanabe, R.M.
dc.contributor.authorWatkins, H.
dc.contributor.authorWei, W.B.
dc.contributor.authorWickremasinghe, A.R.
dc.contributor.authorWillemsen, G.
dc.contributor.authorWilson, J.F.
dc.contributor.authorWong, T.Y.
dc.contributor.authorWu, J.Y.
dc.contributor.authorXiang, A.H.
dc.contributor.authorYanek, L.R.
dc.contributor.authorYengo, L.
dc.contributor.authorYokota, M.
dc.contributor.authorZeggini, E.
dc.contributor.authorZheng, W.
dc.contributor.authorZonderman, A.B.
dc.contributor.authorRotter, J.I.
dc.contributor.authorGloyn, A.L.
dc.contributor.authorMcCarthy, M.I.
dc.contributor.authorDupuis, J.
dc.contributor.authorMeigs, J.B.
dc.contributor.authorScott, R.A.
dc.contributor.authorProkopenko, I.
dc.contributor.authorLeong, A.
dc.contributor.authorLiu, C.T.
dc.contributor.authorParker, S.C.J.
dc.contributor.authorMohlke, K.L.
dc.contributor.authorLangenberg, C.
dc.contributor.authorWheeler, E.
dc.contributor.authorMorris, A.P.
dc.contributor.authorBarroso, I.
dc.contributor.authorMeta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC) Collaborators.
dc.date.accessioned2021-06-30T08:02:00Z
dc.date.available2021-06-30T08:02:00Z
dc.date.issued2021
dc.identifier.citationNature Genetics. 2021; 53(6):840-860.en_US
dc.identifier.issn1061-4036 (Print)
dc.identifier.issn1546-1718 (Electronic)
dc.identifier.issn1061-4036 (Linking)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/23045
dc.descriptionIndexed in MEDLINEen_US
dc.description.abstractABSTRACT: Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.en_US
dc.language.isoen_USen_US
dc.publisherNature Pub. Co.en_US
dc.subjectglycemic traitsen_US
dc.titleThe Trans-ancestral genomic architecture of glycemic traitsen_US
dc.typeArticleen_US
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.