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DC Field | Value | Language |
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dc.contributor.author | Baminiwatta, A. | |
dc.contributor.author | Gunathilake, R. | |
dc.contributor.author | Arambepola, S. | |
dc.contributor.author | Arambepola, M. | |
dc.date.accessioned | 2021-05-20T08:04:33Z | |
dc.date.available | 2021-05-20T08:04:33Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Sri Lanka. Sri Lanka Journal of Child Health.2021; 50(1): 116–123. | en_US |
dc.identifier.issn | 2386-110X | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/22328 | |
dc.description | In Scopus; Not indexed in MEDLINE | en_US |
dc.description.abstract | BACKGROUND: Poor adherence to iron chelation may underlie the detrimental levels of iron overload previously reported among transfusion-dependent thalassaemia (TDT) patients in Sri Lanka. Given the many challenges faced by these patients and families, psychosocial factors may have a significant impact on medication adherence. OBJECTIVE: To assess chelation adherence among TDT patients and explore associated psychosocial factors. METHOD: TDT patients, aged over 4 years, admitted for blood transfusion to a tertiary care hospital, as well as their mothers, were recruited. Medication adherence was assessed using a questionnaire adapted from Brief Adherence Rating Scale. Serum ferritin (SF) values were recorded as objective measures of non-adherence. Mental health status of patients and their mothers was assessed using Strengths and Difficulties Questionnaire (SDQ) and General Health Questionnaire-30 (GHQ) respectively. Associated psychosocial factors were analysed using multiple linear regression. RESULTS: Fifty-two patients aged 4 to 28 years participated. Thirty-four (65%) were female. The average adherence rate was 90%. One fifth of patients had an adherence percentage less than 80%. The mean ferritin level was 3260 ng/ml, whereas 46.2% of patients had SF levels exceeding 2500ng/ml. SF levels correlated positively with non-adherence (r=0.34, 95%CI: 0.071-0.606, p=0.014). Based on multivariate analysis, increasing age and lower SDQ score of patient, lower educational level and greater GHQ-30 score of mother were independent predictors of higher SF levels, but not of adherence rates. CONCLUSIONS: In the paediatric unit of National Hospital, Kandy, 46% of patients had SF levels >2500 ng/ml. There was a significant correlation between SF levels and medication non-adherence (r=0.34, p=0.014). On multivariate analysis, increasing age and lower SDQ score of the patient, lower educational level and greater GHQ-30 score of the mother were independent predictors of higher SF levels, but not of adherence rates. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Sri Lanka College of Paediatricians | en_US |
dc.subject | thalassaemia | en_US |
dc.title | Non-adherence to chelation therapy and associated psychosocial factors among transfusion-dependent thalassaemia patients in Kandy, Sri Lanka | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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Non-adherence to chelation therapy.pdf | 381.82 kB | Adobe PDF | View/Open |
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