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Title: | Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics |
Authors: | Rottoli, M. Tanzanu, M. Di Candido, F. Colombo, F. Frontali, A. Chandrasinghe, P.C. Pellino, G. Frasson, M. Warusavitarne, J. Panis, Y. Sampietro, G.M. Spinelli, A. Poggioli, G. |
Keywords: | Neoplasms ulcerative colitis |
Issue Date: | 2020 |
Publisher: | Elsevier |
Citation: | Digestive and Liver Disease.2020; 52(1):33-37. [Epub 2019 Sep 30] |
Abstract: | BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery. AIM: To identify the risk factors for N+ cancer in UC patients. METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses. RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+. CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients. KEYWORDS: Cancer; Lymph nodes; Ulcerative colitis. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/22302 |
ISSN: | 1590-8658 (Print) 1878-3562 (Electronic) 1590-8658 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
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