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DC Field | Value | Language |
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dc.contributor.author | Siriwardana, R.C. | |
dc.contributor.author | Jayatunge, D.S.P. | |
dc.contributor.author | Ekanayake, C.S. | |
dc.contributor.author | Tilakaratne, S. | |
dc.contributor.author | Niriella, M.A. | |
dc.contributor.author | Gunetilleke, B. | |
dc.contributor.author | Dassanayake, A.S. | |
dc.date.accessioned | 2020-10-14T08:12:31Z | |
dc.date.available | 2020-10-14T08:12:31Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Egyptian Liver Journal. 2020; 10(1): 46 | en_US |
dc.identifier.issn | 2090-6218 (Electronic) | |
dc.identifier.issn | 2090-6226 | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/21422 | |
dc.description | Indexed in Scopus; Not Indexed in MEDLINE | en_US |
dc.description.abstract | BACKGROUND: Cholestasis is due to the obstruction at any level of the excretory pathway of bile. One particularly troublesome symptom of cholestasis is pruritus which leads to a profound effect on a patient’s quality of life. In children with progressive familial intrahepatic cholestasis (PFIC), medical treatment often fails. An alternative surgical procedure using biliary diversion offers significant relief for intractable pruritus in non-responders. CASE PRESENTATION: A 43-year-old male presented with a history of persistent jaundice and intractable pruritus for a 2-month duration. His liver enzymes were markedly elevated. However, his liver synthetic function was preserved. After extensive evaluation, a cause for cholestasis was not identified. A multi-disciplinary decision was to consider liver transplantation, but as his liver synthetic functions were remarkably preserved and the intractable pruritus was the sole indication for a transplantation, it was finally decided that internal biliary diversion should be done for symptomatic relief. His pruritus dramatically improved at 6 weeks post-operative. His liver enzymes and bilirubin levels also decreased compared to his pre-operative status. Currently, his liver functions are being closely monitored. CONCLUSION: Though it is not used in adults, the experience of biliary diversion in children with PFIC shows that there is a considerable improvement of symptoms and postpone the need for a transplant. In our patient, liver function and bilirubin as expected did not show a major improvement. But the dramatic improvement of the symptoms gave us the time to postpone the liver transplantation. A biliary diversion is a reasonable option that needs to be considered even in adults with refectory pruritus due to cholestasis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature | en_US |
dc.subject | Cholestasis, Intrahepatic | en_US |
dc.subject | Cholestasis, Intrahepatic-complications | en |
dc.subject | Pruritus | en |
dc.subject | Liver transplantation | |
dc.title | Internal biliary diversion to avoid liver transplantation in an adult with intractable pruritus due to idiopathic intrahepatic cholestasis | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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Internal biliary diversion to avoid liver.pdf | 470.93 kB | Adobe PDF | View/Open |
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