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DC Field | Value | Language |
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dc.contributor.author | de Silva, A.P. | en_US |
dc.contributor.author | Nandasiri, S.D. | en_US |
dc.contributor.author | Hewavisenthi, J. | en_US |
dc.contributor.author | Manamperi, A. | en_US |
dc.contributor.author | Ariyasinghe, M.P. | en_US |
dc.contributor.author | Dassanayake, A.S. | en_US |
dc.contributor.author | Jewell, D.P. | en_US |
dc.contributor.author | de Silva, H.J. | en_US |
dc.date.accessioned | 2014-10-29T09:33:32Z | - |
dc.date.available | 2014-10-29T09:33:32Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Scandinavian Journal of Gastroenterology; 47(6): pp.619-24 | en_US |
dc.identifier.issn | 0036-5521 (Print) | en_US |
dc.identifier.issn | 1502-7708 (Electronic) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/2131 | - |
dc.description.abstract | BACKGROUND AND AIMS: There is evidence for low-grade inflammation in the pathophysiology of post-infectious irritable bowel syndrome (IBS). We assessed the degree of subclinical intestinal mucosal inflammation in diarrhea-predominant IBS (IBS-D) in a tropical setting. MATERIAL AND METHODS: In a prospective study over 1 year, we investigated 49 patients with IBS-D (cases; median age 34 years (range 18-59); M:F 36:13), diagnosed on Rome III criteria. 14 individuals with a family history of colon cancer (median age 46.5 years (range 23-56); M:F 6:8) were selected as controls. Stools of cases and controls were tested for calprotectin. During colonoileoscopy, serial biopsies were obtained. Mucosal mast cells, neutrophils, eosinophils and lymphocytes/plasma cell infiltrate were quantified. Tissue expression of IL-8 and IL-10 was assessed in biopsies by semi-quantitative RT-PCR. RESULTS: A history suggestive of an episode of infectious diarrhea (ID) was present in 16/49 cases and 0/14 controls (p = 0.013). In cases, there were significantly more mucosal mast cells in the ileum and all segments of colon and significantly more eosinophils in the cecum. Tissue expression of IL-8 was significantly higher and IL-10 significantly lower in cases compared with controls (target/standard cDNA ratio, median (range) IL-8: 1.25 (0.75-2) vs. 0.85 (0.63-1.3), p < 0.0001, Mann-Whitney U test; IL-10: 0.33 (0-0.63) vs. 0.55 (0.5-0.7), p < 0.0001). There was a significant inverse correlation between IL-8 and IL-10 expression (Pearson correlation, (-) 0.509; p < 0.01). CONCLUSION: There was evidence of subclinical intestinal mucosal inflammation in patients with IBS-D. The finding of increased eosinophils is novel, and may be of special relevance to IBS-D in the tropics. | - |
dc.publisher | Informa Healthcare | en_US |
dc.title | Subclinical mucosal inflammation in diarrhea-predominant irritable bowel syndrome (IBS) in a tropical setting | en_US |
dc.type | Article | en_US |
dc.identifier.department | Medicine | en_US |
dc.identifier.department | Pathology | en_US |
dc.identifier.department | Molecular Medicine Unit | en_US |
dc.identifier.department | Pharmacology | en_US |
dc.description.note | Indexed in MEDLINE | en_US |
Appears in Collections: | Journal/Magazine Articles |
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