Medicinal importance of Ferula asafetida oligo-gum resins against infective diseases

Abstract

Ferula foetida oligo-gum resin containing phytochemicals with anti-viral properties. In order to investigate medicinal values of ferula assa-foetida a literature searches were performed through PubMed and PMC academic publications. It contains five sesquiterpene cumarines namely, conferone, badrakemin, feslol, Isosamarcandin and samarcandin with anti-viral properties against Rhinovims (HR V) and Influenza A HINI_ Farnesiferol C and Famesiferol b are novel chemical scaffolds with HR V -2 inhibiting potential at low micromole and mode of inhibition action was prevention of rhinovims adsorption (HR V-2) and/or uncoatmg of the capsid of virus. 5'S-hydroxyumbe11iprenin and 8'-acetoxy- 5'S-hydroxyumbe11iprenin, methyl galbanate, galbanic acid, famesiferol-C, famesiferol-A, conferol showed greater potency against influenza A vims (H IN 1) (IC50 0.26-0.86 pg/mL) than amantadine. Several studies demonstrated that cytotoxic and antitumor activity of Galbanic acid. Additionally, exhibits anti-bacterial effects, anti—diabetic effects, anti- fungal, antiulcer genic effect and hypotensive effects. Asafoetida oligo-gum resin will be beneficial in anti-viral drug productions against disease forming viruses.