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Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/21132
Title: The Impact of empirical hydrocortisone therapy on clinical outcomes in dengue fever: A retrospective chart review
Authors: de Mel, S.
Thilakawardana, B.U.
de Mel, P.
de Silva, A.P.
de Mel, C.
Chandrasena, L.
Seneviratne, S.L.
Abeysuriya, V.
Keywords: Dengue-drug therapy
Severe Dengue
Hydrocortisone
Retrospective Studies
Cohort Studies
Issue Date: 2020
Publisher: Oxford University Press
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2020;114(8): 632-634.
Abstract: BACKGROUND: The role of steroids in dengue infection (DI) remains uncertain. METHODS: A retrospective chart review was conducted on patients ≥18 y of age diagnosed with DI based on positivity for dengue non-structural antigen 1 or immunoglobulin M between October 2017 and November 2018. RESULTS: Hydrocortisone was administered to 106 of 406 patients. DI with warning signs occurred in nine patients (9.5%) in the steroid cohort and eight patients (2.5%) in the non-steroid group. The incidence of severe DI, bleeding and admission duration were similar between the groups. CONCLUSIONS: Our study shows no significant benefit of empirical steroids in DI. KEYWORDS: clinical outcomes; corticosteroids; dengue.
Description: Indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/21132
ISSN: 0035-9203 (Print)
1878-3503 (Electronic)
0035-9203 (Linking)
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