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Title: Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection
Authors: Blacksell, S.D.
Tanganuchitcharnchai, A.
Jarman, R.G.
Gibbons, R.V.
Paris, D.H.
Bailey, M.S.
Day, N.P.
Premaratna, R.
Lalloo, D.G.
de Silva, H.J.
Issue Date: 2011
Publisher: American Society for Microbiology
Citation: Clinical and Vaccine Immunology; 18(10): pp.1773-75
Abstract: A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.
ISSN: 1556-6811 (Print)
1556-679X (Electronic)
Appears in Collections:Journal/Magazine Articles

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