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|Title:||Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection|
de Silva, H.J.
|Publisher:||American Society for Microbiology|
|Citation:||Clinical and Vaccine Immunology; 18(10): pp.1773-75|
|Abstract:||A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.|
|Appears in Collections:||Journal/Magazine Articles|
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