Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection

Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/2035

Title:	Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection
Authors:	Blacksell, S.D. Tanganuchitcharnchai, A. Jarman, R.G. Gibbons, R.V. Paris, D.H. Bailey, M.S. Day, N.P. Premaratna, R. Lalloo, D.G. de Silva, H.J.
Issue Date:	2011
Publisher:	American Society for Microbiology
Citation:	Clinical and Vaccine Immunology; 18(10): pp.1773-75
Abstract:	A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.
URI:	http://repository.kln.ac.lk/handle/123456789/2035
ISSN:	1556-6811 (Print) 1556-679X (Electronic)
Appears in Collections:	Journal/Magazine Articles

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