Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/20296
Title: Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Authors: Bentley, A.R.
Chasman, D. I.
Schwander, K.
Ntalla, I.
Kraja, A.T.
Winkler, T.W.
Brown, M. R.
Sung, Y. J.
Lim, E.
Huffman, J.E.
Vojinovic, D.
Sim, X.
Cheng, C.Y.
Lu, Y.
Liu, J.
Guo, X.
Deng, X.
Musani, S.K.
Li, C.
Feitosa, M.F.
Richard, M.A.
Noordam, R.
Baker, J.
Chen, G.
Aschard, H.
Bartz, T.M.
Ding, J.
Dorajoo, R.
Manning, A.K.
Rankinen, T.
Smith, A. V.
Tajuddin, S.M.
Zhao, W.
Graff, M.
Alver, M.
Boissel, M.
Chai, J. F.
Chen, X.
Divers, J.
Evangelou, E.
Gao, C.
Goel, A.
Hagemeijer, Y.
Harris, S. E.
Hartwig, F. P.
He, M.
Horimoto, A.R.V. R.
Hsu, F.C.
Hung, Y. J.
Jackson, A. U.
Kasturiratne, A.
Komulainen, P.
Kühnel, B.
Leander, K.
Lin, K. H.
Luan, J.
Lyytikäinen, L.P.
Matoba, N.
Nolte, I. M.
Pietzner, M.
Prins, B.
Riaz, M.
Robino, A.
Said, M. A.
Schupf, N.
Scott, R. A.
Sofer, T.
Stancáková, A.
Takeuchi, F.
Tayo, B. O.
van der Most, P. J.
Varga, T. V.
Wang, T. D.
Wang, Y.
Ware, E. B.
Wen, W.
Xiang, Y. B.
Yanek, L. R.
Zhang, W.
Zhao, J. H.
Adeyemo, A.
Afaq, S.
Amin, N.
Amini, M.
Arking, D.E.
Arzumanyan, Z.
Aung, T.
Ballantyne, C.
Barr, R. G.
Bielak, L. F.
Boerwinkle, E.
Bottinger, E.P.
Broeckel, U.
Chen, Y. I.
Charumathi, S.
Canouil, M.
Campbell, A.
Cade, B. E.
Brown, M.
Christensen, K.
de Las Fuentes, L.
Connell, J. M.
Concas, M. P.
COGENT-Kidney Consortium
de Silva, H.J.
de Vries, P. S.
Doumatey, A.
Duan, Q.
Eaton, C. B.
Eppinga, R.N.
Faul, J. D.
Floyd, J.S.
Gigante, B.
Gharib, S. A.
Forouhi, N.G.
Ghanbari, M.
Gao, H.
Gandin, I.
Friedlander, Y.
Forrester, T.
Hixson, J. E.
Hirata, M.
Justice, A. E.
Jonas, J. B.
Johnson, C.
Joehanes, R.
Jia, Y.
EPIC-InterAct Consortium
Ikram, M.A.
Katsuya, T.
Khor, C.C.
Kilpeläinen, T.O.
Koh, W. P.
Kolcic, I.
Kooperberg, C.
Krieger, J.E.
Kritchevsky, S.B.
Kubo, M.
Kuusisto, J.
Lakka, T. A.
Langefeld, C.D.
Langenberg, C.
Launer, L. J.
Lehne, B.
Lewis, C. E.
Li, Y.
Liang, J.
Lin, S.
Liu, C.T.
Liu, J.
Liu, K.
Loh, M.
Lohman, K.K.
Louie, T.
Luzzi, A.
Mägi, R.
Mahajan, A.
Manichaikul, A.W.
McKenzie, C.A.
Meitinger, T.
Metspalu, A.
Milaneschi, Y.
Milani, L.
Mohlke, K. L.
Momozawa, Y.
Morris, A. P.
Murray, A. D.
Nalls, M. A.
Nauck, M.
Nelson, C. P.
North, K. E.
O'Connell, J.R.
Palmer, N.D.
Papanicolau, G.J.
Pedersen, N. L.
Peters, A.
Peyser, P. A.
Polasek, O.
Poulter, N.
Raitakari, O.T.
Reiner, A. P.
Renström, F.
Rice, T.K.
Rich, S.S.
Robinson, J.G.
Rose, L. M.
Rosendaal, F. R.
Rudan, I.
Schmidt, C.O.
Schreiner, P. J.
Scott, W.R.
Sever, P.
Shi, Y.
Sidney, S.
Sims, M.
Smith, J. A.
Snieder, H.
Starr, J. M.
Strauch, K.
Stringham, H. M.
Tan, N. Y. Q.
Tang, H.
Taylor, K. D.
Teo, Y. Y.
Tham, Y. C.
Tiemeier, H.
Turner, S. T.
Uitterlinden, A. G.
Understanding Society Scientific Group
van Heemst, D.
Waldenberger, M.
Wang, H.
Wang, L.
Wang, L.
Wei, W. B.
Williams, C. A.
Wilson, G. Sr.
Wojczynski, M. K.
Yao, J.
Young, K.
Yu, C.
Yuan, J. M.
Zhou, J.
Zonderman, A. B.
Becker, D. M.
Boehnke, M.
Bowden, D. W.
Chambers, J. C.
Cooper, R. S.
de Faire, U.
Deary, I. J.
Elliott, P.
Esko, T.
Farrall, M.
Franks, P. W.
Freedman, B. I.
Froguel, P.
Gasparini, P.
Gieger, C.
Horta, B. L.
Juang, J. J.
Kamatani, Y.
Kammerer, C. M.
Kato, N.
Kooner, J. S.
Laakso, M.
Laurie, C. C.
Lee, I. T.
Lehtimäki, T.
Lifelines Cohort
Magnusson, P. K. E.
Oldehinkel, A. J.
Penninx, B. W. J. H.
Pereira, A. C.
Rauramaa, R.
Redline, S.
Samani, N. J.
Scott, J.
Shu, X. O.
van der Harst, P.
Wagenknecht, L. E.
Wang, J. S.
Wang, Y. X.
Wareham, N. J.
Watkins, H.
Weir, D. R.
Wickremasinghe, A.R.
Wu, T.
Zeggini, E.
Zheng, W.
Bouchard, C.
Evans, M. K.
Gudnason, V.
Kardia, S. L. R.
Liu, Y.
Psaty, B. M.
Ridker, P. M.
van Dam, R. M.
Mook-Kanamori, D. O.
Fornage, M.
Province, M. A.
Kelly, T. N.
Fox, E. R.
Hayward, C.
van Duijn, C. M.
Tai, E. S.
Wong, T. Y.
Loos, R. J. F.
Franceschini, N.
Rotter, J. I.
Zhu, X.
Bierut, L. J.
Gauderman, W. J.
Rice, K.
Munroe, P. B.
Morrison, A. C.
Rao, D. C.
Cupples, L. A.
Rotimi, C. N.
Keywords: Smoking
Issue Date: 2019
Publisher: Nature Publishing Group
Citation: Nature Genetics.2019;51(4):636-648
Abstract: The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Description: indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/20296
ISSN: 1061-4036 (Print)
1546-1718 (Electronic)
Appears in Collections:Journal/Magazine Articles

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