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dc.contributor.authorKilpeläinen, T.O.
dc.contributor.authorBentley, A.R.
dc.contributor.authorNoordam, R.
dc.contributor.authorSung, Y. J.
dc.contributor.authorSchwander, K.
dc.contributor.authorWinkler, T. W.
dc.contributor.authorJakupović, H.
dc.contributor.authorChasman, D. I.
dc.contributor.authorManning, A.
dc.contributor.authorNtalla, I.
dc.contributor.authorAschard, H.
dc.contributor.authorBrown, M. R.
dc.contributor.authorde Las Fuentes, L.
dc.contributor.authorFranceschini, N.
dc.contributor.authorGuo, X.
dc.contributor.authorVojinovic, D.
dc.contributor.authorAslibekyan, S.
dc.contributor.authorFeitosa, M. F.
dc.contributor.authorKho, M.
dc.contributor.authorMusani, S. K.
dc.contributor.authorRichard, M.
dc.contributor.authorWang, H.
dc.contributor.authorWang, Z.
dc.contributor.authorBartz, T. M.
dc.contributor.authorBielak, L. F.
dc.contributor.authorCampbell, A.
dc.contributor.authorDorajoo, R.
dc.contributor.authorFisher, V.
dc.contributor.authorHartwig, F. P.
dc.contributor.authorHorimoto, A. R. V. R.
dc.contributor.authorLi, C.
dc.contributor.authorLohman, K. K.
dc.contributor.authorMarten, J.
dc.contributor.authorSim, X.
dc.contributor.authorSmith, A. V.
dc.contributor.authorTajuddin, S. M.
dc.contributor.authorAlver, M.
dc.contributor.authorAmini, M.
dc.contributor.authorBoissel, M.
dc.contributor.authorChai, J. F.
dc.contributor.authorChen, X.
dc.contributor.authorDivers, J.
dc.contributor.authorEvangelou, E.
dc.contributor.authorGao, C.
dc.contributor.authorGraff, M.
dc.contributor.authorHarris, S. E.
dc.contributor.authorHe, M.
dc.contributor.authorHsu, F. C.
dc.contributor.authorJackson, A. U.
dc.contributor.authorZhao, J. H.
dc.contributor.authorKraja, A. T.
dc.contributor.authorKühnel, B.
dc.contributor.authorLaguzzi, F.
dc.contributor.authorLyytikäinen, L. P.
dc.contributor.authorNolte, I. M.
dc.contributor.authorRauramaa, R.
dc.contributor.authorRiaz, M.
dc.contributor.authorRobino, A.
dc.contributor.authorRueedi, R.
dc.contributor.authorStringham, H. M.
dc.contributor.authorTakeuchi, F.
dc.contributor.authorvan der Most, P. J.
dc.contributor.authorVarga, T. V.
dc.contributor.authorVerweij, N.
dc.contributor.authorWare, E. B.
dc.contributor.authorWen, W.
dc.contributor.authorLi, X.
dc.contributor.authorYanek, L. R.
dc.contributor.authorAmin, N.
dc.contributor.authorArnett, D. K.
dc.contributor.authorBoerwinkle, E.
dc.contributor.authorBrumat, M.
dc.contributor.authorCade, B.
dc.contributor.authorCanouil, M.
dc.contributor.authorChen, Y. I.
dc.contributor.authorConcas, M. P.
dc.contributor.authorConnell, J.
dc.contributor.authorde Mutsert, R.
dc.contributor.authorde Silva, H.J.
dc.contributor.authorde Vries, P.S.
dc.contributor.authorDemirkan, A.
dc.contributor.authorDing, J.
dc.contributor.authorEaton, C. B.
dc.contributor.authorFaul, J. D.
dc.contributor.authorFriedlander, Y.
dc.contributor.authorGabriel, K. P.
dc.contributor.authorGhanbari, M.
dc.contributor.authorGiulianini, F.
dc.contributor.authorGu, C. C.
dc.contributor.authorGu, D.
dc.contributor.authorHarris, T. B.
dc.contributor.authorHe J, J.
dc.contributor.authorHeikkinen, S.
dc.contributor.authorHeng, C. K.
dc.contributor.authorHunt, S. C.
dc.contributor.authorIkram, M. A.
dc.contributor.authorJonas, J. B.
dc.contributor.authorKoh, W. P.
dc.contributor.authorKomulainen, P.
dc.contributor.authorKrieger, J. E.
dc.contributor.authorKritchevsky, S. B.
dc.contributor.authorKutalik, Z.
dc.contributor.authorKuusisto, J.
dc.contributor.authorLangefeld, C. D.
dc.contributor.authorLangenberg, C.
dc.contributor.authorLauner, L. J.
dc.contributor.authorLeander, K.
dc.contributor.authorLemaitre, R. N.
dc.contributor.authorLewis, C. E.
dc.contributor.authorLiang, J.
dc.contributor.authorLifelines Cohort Study
dc.contributor.authorLiu, J.
dc.contributor.authorMägi, R.
dc.contributor.authorManichaikul, A.
dc.contributor.authorMeitinger, T.
dc.contributor.authorMetspalu, A.
dc.contributor.authorMilaneschi, Y.
dc.contributor.authorMohlke, K. L.
dc.contributor.authorMosley, T. H.
dc.contributor.authorMurray, A. D.
dc.contributor.authorNalls, M. A.
dc.contributor.authorNang, E. K.
dc.contributor.authorNelson, C. P.
dc.contributor.authorNona, S.
dc.contributor.authorNorris, J. M.
dc.contributor.authorNwuba, C. V.
dc.contributor.authorO'Connell, J.
dc.contributor.authorPalmer, N. D.
dc.contributor.authorPapanicolau, G. J.
dc.contributor.authorPazoki, R.
dc.contributor.authorPedersen, N. L.
dc.contributor.authorPeters, A.
dc.contributor.authorPeyser, P. A.
dc.contributor.authorPolasek, O.
dc.contributor.authorPorteous, D. J.
dc.contributor.authorPoveda, A.
dc.contributor.authorRaitakari, O. T.
dc.contributor.authorRich, S. S.
dc.contributor.authorRisch, N.
dc.contributor.authorRobinson, J. G.
dc.contributor.authorRose, L. M.
dc.contributor.authorRudan, I.
dc.contributor.authorSchreiner, P. J.
dc.contributor.authorScott, R. A.
dc.contributor.authorSidney, S. S.
dc.contributor.authorSims, M.
dc.contributor.authorSmith, J. A.
dc.contributor.authorSnieder, H.
dc.contributor.authorSofer, T.
dc.contributor.authorStarr, J. M.
dc.contributor.authorSternfeld, B.
dc.contributor.authorStrauch, K.
dc.contributor.authorTang, H.
dc.contributor.authorTaylor, K. D.
dc.contributor.authorTsai, M. Y.
dc.contributor.authorTuomilehto, J.
dc.contributor.authorUitterlinden, A. G.
dc.contributor.authorvan der Ende, M. Y.
dc.contributor.authorvan Heemst, D.
dc.contributor.authorVoortman, T.
dc.contributor.authorWaldenberger, M.
dc.contributor.authorWennberg, P.
dc.contributor.authorWilson, G.
dc.contributor.authorXiang, Y. B.
dc.contributor.authorYao, J.
dc.contributor.authorYu, C.
dc.contributor.authorYuan, J. M.
dc.contributor.authorZhao, W.
dc.contributor.authorZonderman, A. B.
dc.contributor.authorBecker, D. M.
dc.contributor.authorBoehnke, M.
dc.contributor.authorBowden, D. W.
dc.contributor.authorde Faire, U.
dc.contributor.authorDeary, I. J.
dc.contributor.authorElliott, P.
dc.contributor.authorEsko, T.
dc.contributor.authorFreedman, B. I.
dc.contributor.authorFroguel, P.
dc.contributor.authorGasparini, P.
dc.contributor.authorGieger, C.
dc.contributor.authorKato, N.
dc.contributor.authorLaakso, M.
dc.contributor.authorLakka, T. A.
dc.contributor.authorLehtimäki, T.
dc.contributor.authorMagnusson, P. K. E.
dc.contributor.authorOldehinkel, A. J.
dc.contributor.authorPenninx, B. W. J. H.
dc.contributor.authorSamani, N. J.
dc.contributor.authorShu, X. O.
dc.contributor.authorvan der Harst, P.
dc.contributor.authorVan Vliet-Ostaptchouk, J. V.
dc.contributor.authorVollenweider, P.
dc.contributor.authorWagenknecht, L. E.
dc.contributor.authorWang, Y. X.
dc.contributor.authorWareham, N. J.
dc.contributor.authorWeir, D. R.
dc.contributor.authorWu, T.
dc.contributor.authorZheng, W.
dc.contributor.authorZhu, X.
dc.contributor.authorEvans, M. K.
dc.contributor.authorFranks, P. W.
dc.contributor.authorGudnason, V.
dc.contributor.authorHayward, C.
dc.contributor.authorHorta, B. L.
dc.contributor.authorKelly, T. N.
dc.contributor.authorLiu, Y.
dc.contributor.authorNorth, K. E.
dc.contributor.authorPereira, A. C.
dc.contributor.authorRidker, P. M.
dc.contributor.authorTai, E. S.
dc.contributor.authorvan Dam, R. M.
dc.contributor.authorFox, E. R.
dc.contributor.authorKardia, S. L. R.
dc.contributor.authorLiu, C. T.
dc.contributor.authorProvince, M. A.
dc.contributor.authorMook-Kanamori, D. O.
dc.contributor.authorRedline, S.
dc.contributor.authorvan Duijn, C. M.
dc.contributor.authorRotter, J. I.
dc.contributor.authorKooperberg, C. B.
dc.contributor.authorGauderman, W. J.
dc.contributor.authorPsaty, B. M.
dc.contributor.authorRice, K.
dc.contributor.authorMunroe, P. B.
dc.contributor.authorFornage, M.
dc.contributor.authorCupples, L. A.
dc.contributor.authorRotimi, C. N.
dc.contributor.authorMorrison, A. C.
dc.contributor.authorRao, D. C.
dc.contributor.authorLoos, R. J. F.
dc.date.accessioned2019-02-22T10:24:52Z
dc.date.available2019-02-22T10:24:52Z
dc.date.issued2019
dc.identifier.citationNature communications.2019;10(1):376en_US
dc.identifier.issn2041-1723 (Electronic)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/19997
dc.descriptionindexed in Medlineen_US
dc.description.abstractMany genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.en_US
dc.language.isoenen_US
dc.publisherNature Publicationsen_US
dc.subjectBlood lipid levelsen_US
dc.titleMulti-ancestry study of blood lipid levels identifies four loci interacting with physical activity.en_US
dc.typeArticleen_US
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