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Title: | First-trimester ultrasound dating of twin pregnancy: are singleton charts reliable? |
Authors: | Dias, T. Mahsud-Dornan, S. Thilaganathan, B. Papageorghiou, A. T. Bhide, A. |
Keywords: | Pregnancy, Twin |
Issue Date: | 2010 |
Publisher: | Wiley |
Citation: | British Journal of Obstetrics and Gynaecology. 2010; 117(8): pp.979-84 |
Abstract: | OBJECTIVE: The aim of this study was to assess the performance of validated singleton crown-rump length (CRL) formulae in dating twin pregnancies at 11-14 weeks of gestation. DESIGN: Retrospective cohort study. SETTING: Fetal medicine unit of a London teaching hospital. SAMPLE: Three hundred and eighty-four pregnancies with known dates of conception. METHODS: Retrospective analysis of 266 singletons and 118 twin pregnancies conceived by in vitro fertilisation (IVF), with a known date of conception. The gestation calculated from the date of conception was compared with the expected gestation from fetal size using a number of different CRL formulae. MAIN OUTCOME MEASURES: Difference in gestational age computed from fetal size (CRL) of the bigger and smaller fetus in twin pregnancies and singleton pregnancies using three formulae. RESULTS: Two of the three studied CRL formulae systematically underestimated the mean gestational age and size of singleton IVF pregnancies (Robinson formula: gestation = 1.4 days, size = 2.7 mm). Twin CRL measurements straddled those of singletons, regardless of the CRL formula used (Robinson formula: larger twin gestation = 2.4 days, size = 4.7 mm; smaller twin gestation = 0.8 days, size = 1.7 mm). These underestimates in gestation and size for IVF singleton and twin pregnancies are well within the known limits of accuracy of first = trimester ultrasound measurements, and are of limited clinical significance. CONCLUSIONS: Currently available CRL charts underestimate both the age and size of IVF singleton pregnancies by a clinically insignificant amount. This difference is similar for twin pregnancies, suggesting that singleton CRL charts can be used to date twin pregnancies accurately. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1982 |
ISSN: | 1470-0328 (Print) 1471-0528 (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
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