Digital Repository, University of Kelaniya Medicine Journal/Magazine Articles

 
Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1946
Title: Immunophenotypic distinction between pigmented villonodular synovitis and haemosiderotic synovitis
Authors: Mahendra, G.
Kliskey, K.
Athanasou, N.A.
Issue Date: 2010
Publisher: BMJ Publishing Group
Citation: Journal of Clinical Pathology; 63(1): pp.75-8
Abstract: AIM: Haemosiderotic synovitis (HS) is caused by excessive bleeding into a joint. It occurs secondary to a variety of conditions and needs to be distinguished from pigmented villonodular synovitis (PVNS) for the purposes of treatment. The histopathological distinction between these conditions, particularly in biopsy specimens, can be problematic. METHODS: Immunophenotypic findings in 20 cases of PVNS and 20 cases of HS were analysed using monoclonal antibodies against proliferation (Ki-67), apoptosis (bcl2), macrophage (CD14, CD68, HLA-DR) and osteoclast (CD51) antigens. RESULTS: Macrophages in PVNS and HS expressed CD14 and HLA-DR. The giant cells in PVNS, but not those in HS, expressed CD51 and were negative for CD14 and HLA-DR, indicating that these cells had an osteoclast phenotype. Considerably more CD51-expressing mononuclear cells were noted in PVNS compared with HS. The Ki-67 proliferation index was higher in PVNS than in HS. CONCLUSIONS: The findings indicate that there are immunophenotypic differences in giant cells between PVNS and HS, and that expression of CD51 and a high Ki-67 index effectively distinguishes between these two conditions
URI: http://repository.kln.ac.lk/handle/123456789/1946
ISSN: 0021-9746 (Print)
1472-4146 (Electronic)
Appears in Collections:Journal/Magazine Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.