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Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/18919
Title: Effect of antimicrobial agents on inflammatory cytokines in acute Leptospirosis
Authors: Fernando, N.
de Silva, R.
Hadunnetti, S.M.
Karunanayake, L.
de Silva, N.L.
de Silva, H.J.
Rajapakse, S.
Premawansa, S.
Keywords: Leptospirosis
Leptospirosis-Drug therapy
Anti-Infective Agents
Anti-Infective Agents-therapeutic use
Cytokines-blood
Issue Date: 2018
Publisher: American Society for Microbiology
Citation: Antimicrobial Agents and Chemotherapy.2018;62(5):e02312-17
Abstract: The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (P = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses (P < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = -0.315; P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.
Description: Indexed In MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/18919
ISSN: 0066-4804 (Print)
1098-6596 (Electronic)
0066-4804 (Linking)
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