Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/18874
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFeitosa, M.F.
dc.contributor.authorKraja, A.T.
dc.contributor.authorChasman, D.I.
dc.contributor.authorSung, Y.J.
dc.contributor.authorWinkler, T.W.
dc.contributor.authorNtalla, I.
dc.contributor.authorGuo, X.
dc.contributor.authorFranceschini, N.
dc.contributor.authorCheng, C.Y.
dc.contributor.authorSim, X.
dc.contributor.authorVojinovic, D.
dc.contributor.authorMarten, J.
dc.contributor.authorMusani, S.K.
dc.contributor.authorLi, C.
dc.contributor.authorBentley, A.R.
dc.contributor.authorBrown, M.R.
dc.contributor.authorScwander, K.
dc.contributor.authorRichard, M.A.
dc.contributor.authorNoordam, R.
dc.contributor.authorAschard, H.
dc.contributor.authorBartz, T.M.
dc.contributor.authorBielak, L.F.
dc.contributor.authorDorajoo, R.
dc.contributor.authorFishaer, V.
dc.contributor.authorHartwig, F.P.
dc.contributor.authorHorimoto, A.R.V.R.
dc.contributor.authorLohman, K.K.
dc.contributor.authorManning, A.K.
dc.contributor.authorRankinen, T.
dc.contributor.authorSmith, A.V.
dc.contributor.authorTajiddin, S.M.
dc.contributor.authorWojczynski, M.K.
dc.contributor.authorAlver, M.
dc.contributor.authorBoissel, M.
dc.contributor.authorCai, Q.
dc.contributor.authorCampbell, A.
dc.contributor.authorChai, J.F.
dc.contributor.authorChen, X.
dc.contributor.authorDivers, J.
dc.contributor.authorGao, C.
dc.contributor.authorGoel, A.
dc.contributor.authorHagemeijer, Y.
dc.contributor.authorHarris, S.E.
dc.contributor.authorHe, M.
dc.contributor.authorHsu, F.C.
dc.contributor.authorJackson, A.U.
dc.contributor.authorKahonen, M.
dc.contributor.authorKasturiratne, A.
dc.contributor.authorKomulainen, P.
dc.contributor.authorKuhnel, B.
dc.contributor.authorLaguzzi, F.
dc.contributor.authorLuan, J.
dc.contributor.authorMatoba, N.
dc.contributor.authorNolte, I.M.
dc.contributor.authorPadmanabhan, S.
dc.contributor.authorRiaz, M.
dc.contributor.authorRueedi, R.
dc.contributor.authorRobino, A.
dc.contributor.authorSaid, M.A.
dc.contributor.authorScott, R.A.
dc.contributor.authorSoffer, T.
dc.contributor.authorStancakova, A.
dc.contributor.authorTakeuchi, F.
dc.contributor.authorTayo, B.O.
dc.contributor.authorvan de Most, P.J.
dc.contributor.authorVarga, T.V.
dc.contributor.authorVitart, V.
dc.contributor.authorWang, Y.
dc.contributor.authorWare, E.B.
dc.contributor.authorWarren, H.R.
dc.contributor.authorWeiss, S.
dc.contributor.authorWen, W.
dc.contributor.authorYanek, L.R.
dc.contributor.authorZhang, W.
dc.contributor.authorZhao, J.H.
dc.contributor.authorAfaq, S.
dc.contributor.authorAmin, N.
dc.contributor.authorAmini, M.
dc.contributor.authorArking, D.E.
dc.contributor.authorAung, T.
dc.contributor.authorBoerwinkle, E.
dc.contributor.authorBorecki, I.
dc.contributor.authorBroecki, I.
dc.contributor.authorBroeckel, U.
dc.contributor.authorBrown, M.
dc.contributor.authorBrumat, M.
dc.contributor.authorBurke, G.L.
dc.contributor.authorCanouil, M.
dc.contributor.authorChakravarthi, A.
dc.contributor.authorCharumathi, S.
dc.contributor.authorIda Chen, Y.D.
dc.contributor.authorConnel, J.M.
dc.contributor.authorCorrea, A.
dc.contributor.authorde Las Fuentes, L.
dc.contributor.authorde Mutsert, R.
dc.contributor.authorde Silva, H.J.
dc.contributor.authorDeng, X.
dc.contributor.authorDing, J.
dc.contributor.authorDuan, Q.
dc.contributor.authorEaton, C.B.
dc.contributor.authorEhret, G.
dc.contributor.authorEppinga, R.N.
dc.contributor.authorEvangelou, E.
dc.contributor.authorFaul, J.D.
dc.contributor.authorFelix, S.B.
dc.contributor.authorForouhi, N.G.
dc.contributor.authorForrester, T.
dc.contributor.authorFranco, O.H.
dc.contributor.authorFriedlander, Y.
dc.contributor.authorGandin, I.
dc.contributor.authorGao, H.
dc.contributor.authorGhanbari, M.
dc.contributor.authorGigante, B.
dc.contributor.authorGu, C.C.
dc.contributor.authorGu, D.
dc.contributor.authorHagenaars, S.P.
dc.contributor.authorHalmans, G.
dc.contributor.authorHarris, T.B.
dc.contributor.authorHe, J.
dc.contributor.authorHeikkinen, S.
dc.contributor.authorHeng, C.K.
dc.contributor.authorHirata, M.
dc.contributor.authorHoward, B.V.
dc.contributor.authorIkram, M.A.
dc.contributor.authorInterAct Consortium
dc.contributor.authorJohn, U.
dc.contributor.authorKatsuya, T.
dc.contributor.authorLakka, T.A.
dc.contributor.authorLangefeld, C.D.
dc.contributor.authorLangenberg, C.
dc.contributor.authorLauner, L.J.
dc.contributor.authorLehne, B.
dc.contributor.authorLewis, C.E.
dc.contributor.authorLi, Y.
dc.contributor.authorLin, S.
dc.contributor.authorLin, U.
dc.contributor.authorLiu, J.
dc.contributor.authorLiu, J.
dc.contributor.authorLoh, M.
dc.contributor.authorLouie, T.
dc.contributor.authorMagi, R.
dc.contributor.authorMcKenzie, C.A.
dc.contributor.authorMeitinger, T.
dc.contributor.authorMetspalu, A.
dc.contributor.authorMilaneschi, Y.
dc.contributor.authorMilani, L.
dc.contributor.authormohlke, K.L.
dc.contributor.authorMomozawa, Y.
dc.contributor.authorNalls, M.A.
dc.contributor.authorNelson, C.P.
dc.contributor.authorSotoodehnia, N.
dc.contributor.authorNorris, J.M.
dc.contributor.authorO'Connel, J.R.
dc.contributor.authorPalmer, N.D.
dc.contributor.authorPerls, T.
dc.contributor.authorPedersen, N.L.
dc.contributor.authorPeters, A.
dc.contributor.authorPeyser, P.A.
dc.contributor.authorPoulter, N.
dc.contributor.authorRaffel, L.J.
dc.contributor.authorRaitakari, O.T.
dc.contributor.authorRoll, K.
dc.contributor.authorRose, L.M.
dc.contributor.authorRosendaal, F.R.
dc.contributor.authorRotter, J.I.
dc.contributor.authorSchimidit, C.O.
dc.contributor.authorSchreiner, P.J.
dc.contributor.authorSchupf, N.
dc.contributor.authorScott, W.R.
dc.contributor.authorSever, P.S.
dc.contributor.authorShi, Y.
dc.contributor.authorSidney, S.
dc.contributor.authorSims, M.
dc.contributor.authorSitlani, C.M.
dc.contributor.authorSmith, J.A.
dc.contributor.authorSnieder, H.
dc.contributor.authorStarr, J.M.
dc.contributor.authorStrauch, K.
dc.contributor.authorStringham, H.M.
dc.contributor.authorTan, N.Y.Q.
dc.contributor.authorTang, H.
dc.contributor.authorTaylor, K.D.
dc.contributor.authorTeo, Y.Y.
dc.contributor.authorTham, Y.C.
dc.contributor.authorTurner, S.C.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorVollenweider, P.
dc.contributor.authorWaldenberger, M.
dc.contributor.authorWang, L.
dc.contributor.authorWang, Y.X.
dc.contributor.authorWei, W.B.
dc.contributor.authorWilliams, C.
dc.contributor.authorYao, J.
dc.contributor.authorYuan, J.M.
dc.contributor.authorZhao, W.
dc.contributor.authorZonderman, A.B.
dc.contributor.authorBecker, D.M.
dc.contributor.authorBoehnke, M.
dc.contributor.authorBowden, D.W.
dc.contributor.authorChambers, J.C.
dc.contributor.authorDeary, I.J.
dc.contributor.authorEsco, T.
dc.contributor.authorFarall, M.
dc.contributor.authorFrankd, P.W.
dc.contributor.authorFreedman, B.I.
dc.contributor.authorFroguel, P.
dc.contributor.authorGasparini, P.
dc.contributor.authorGieger, C.
dc.contributor.authorJonas, J.B.
dc.contributor.authorKamatani, Y.
dc.contributor.authorKato, N.
dc.contributor.authorKooner, J.S.
dc.contributor.authorKutalik, Z.
dc.contributor.authorLaakso, M.
dc.contributor.authorLaurie, C.C.
dc.contributor.authorLeander, K.
dc.contributor.authorLehtimaki, T.
dc.contributor.authorStudy, L.C.
dc.contributor.authorMagnusson, P.K.E.
dc.contributor.authorOlderhinkel, A.J.
dc.contributor.authorPenninx, B.W.J.H.
dc.contributor.authorPolasek, O.
dc.contributor.authorPorteous, D.J.
dc.contributor.authorRauramaa, R.
dc.contributor.authorSsamani, N.J.
dc.contributor.authorScott, J.
dc.contributor.authorShu, X.O.
dc.contributor.authorvan der Harst, P.
dc.contributor.authorWagenknecht, L.E.
dc.contributor.authorWareham, N.J.
dc.contributor.authorWatkins, H.
dc.contributor.authorWeir, D.R.
dc.contributor.authorWickremasinghe, A.R.
dc.contributor.authorWu, T.
dc.contributor.authorZheng, W.
dc.contributor.authorBouchard, C.
dc.contributor.authorChristensen, K.
dc.contributor.authorEvans, M.K.
dc.contributor.authorGudnason, V.
dc.contributor.authorHorta, B.L.
dc.contributor.authorKardia, S.L.R.
dc.contributor.authorLiu, Y.
dc.contributor.authorPereira, A.C.
dc.contributor.authorPsaty, B.M.
dc.contributor.authorRidker, P.M.
dc.contributor.authorvan Dam, R.M.
dc.contributor.authorGauderman, W.J.
dc.contributor.authorZhu, X.
dc.contributor.authorMook-Kanamori, D.O.
dc.contributor.authorFornage, M.
dc.contributor.authorRotimi, C.N.
dc.contributor.authorCupples, L.A.
dc.contributor.authorKelly, T.N.
dc.contributor.authorFox, E.R.
dc.contributor.authorHayward, C.
dc.contributor.authorvan Duijn, C.M.
dc.contributor.authorTai, E.S.
dc.contributor.authorWong, T.Y.
dc.contributor.authorKooperberg, C.
dc.contributor.authorPalmas, W.
dc.contributor.authorRice, K.
dc.contributor.authorMorrison, A.C.
dc.contributor.authorElliott, P.
dc.contributor.authorCaulfield, M.J.
dc.contributor.authorMunroe, P.B.
dc.contributor.authorRao, D.C.
dc.contributor.authorProvince, M.A.
dc.contributor.authorLevy, D.
dc.date.accessioned2018-06-29T06:07:56Z
dc.date.available2018-06-29T06:07:56Z
dc.date.issued2018
dc.identifier.citationPLoS one.2018;13(6):e0198166en_US
dc.identifier.issn1932-6203 (Electronic)
dc.identifier.issn1932-6203 (Linking)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/18874
dc.descriptionIndexed In MEDLINEen_US
dc.description.abstractHeavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in ≈440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertensionen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectAlcohol Drinkingen_US
dc.subjectBlood Pressure-geneticsen
dc.subjectHypertension-epidemiologyen
dc.subjectHypertension-geneticsen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectCohort Studies
dc.titleNovel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestriesen_US
dc.typeArticleen_US
Appears in Collections:Journal/Magazine Articles

Files in This Item:
File Description SizeFormat 
pone.0198166.pdf3.1 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.