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Title: | Pre-treatment alphafeto protein in hepatocellular carcinoma with non-viral aetiology - a prospective study |
Authors: | Siriwardana, R.C. Thilakarathne, S. Niriella, M.A. Dassanayake, A.S. Gunetilleke, M.B. Habarakada, L.C.A. de Silva, H.J. |
Keywords: | Carcinoma, Hepatocellular Carcinoma hepatocellular-aetiology Carcinoma, Hepatocellular-therapy alpha-Fetoproteins Prospective Studies |
Issue Date: | 2017 |
Publisher: | BioMed Central |
Citation: | BMC Gastroenterology.2017;17(1):142 |
Abstract: | BACKGROUND: Alpha-fetoprotein (AFP) is a biomarker for hepatocellular carcinoma (HCC). The significance of pre-treatment AFP (pt-AFP) in non-viral HCC (nvHCC) is not clear. METHODS: Patients with nvHCC, referred to a Hepatobiliary Clinic from September 2011-2015 were screened. HCC was diagnosed using American Association for the Study of Liver Disease guidelines, and TNM staged. nvHCC was diagnosed when HBsAg and anti-HCVAb was negative. Child-Turcotte-Pugh (CTP) and Model for End-stage Liver Disease (MELD) scores were calculated. AFP level was evaluated against patient characteristics, tumour characteristics and survival. RESULTS: Three hundred eighty-nine patients with nvHCC [age 64(12-88) years; 344(88.4%) males] were screened. Median AFP was 25.46 ng/ml (1.16-100,000). 41.2% (n = 160) Of patients had normal AFP level. 22.9% (n = 89) had AFP over 400 ng/ml. Female gender (P < 0.05), vascular invasion (P < 0.001), tumours over 5 cm (P < 0.05), late TNM stage (P < 0.001) and non-surgical candidates had higher AFP levels. Diffuse type (P < 0.001), macro vascular invasion (P < 0.001) and late stage tumours (P < 0.001) had AFP over 400 ng/ml. Having AFP below 400 ng/ml was associated with longer survival (16 vs. 7 months, P < 0.001). CONCLUSION: Pre treatment AFP has a limited value In diagnosing nvHCC, Having a AFP value over 400 ng/ml was associated with aggressive tumour behaviour and poor prognosis. |
URI: | http://repository.kln.ac.lk/handle/123456789/18572 |
ISSN: | 1471-230X (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
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BMCgas.2017.pdf | 500.82 kB | Adobe PDF | View/Open |
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