Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/18572
Title: Pre-treatment alphafeto protein in hepatocellular carcinoma with non-viral aetiology - a prospective study
Authors: Siriwardana, R.C.
Thilakarathne, S.
Niriella, M.A.
Dassanayake, A.S.
Gunetilleke, M.B.
Habarakada, L.C.A.
de Silva, H.J.
Keywords: Carcinoma, Hepatocellular
Carcinoma hepatocellular-aetiology
Carcinoma, Hepatocellular-therapy
alpha-Fetoproteins
Prospective Studies
Issue Date: 2017
Publisher: BioMed Central
Citation: BMC Gastroenterology.2017;17(1):142
Abstract: BACKGROUND: Alpha-fetoprotein (AFP) is a biomarker for hepatocellular carcinoma (HCC). The significance of pre-treatment AFP (pt-AFP) in non-viral HCC (nvHCC) is not clear. METHODS: Patients with nvHCC, referred to a Hepatobiliary Clinic from September 2011-2015 were screened. HCC was diagnosed using American Association for the Study of Liver Disease guidelines, and TNM staged. nvHCC was diagnosed when HBsAg and anti-HCVAb was negative. Child-Turcotte-Pugh (CTP) and Model for End-stage Liver Disease (MELD) scores were calculated. AFP level was evaluated against patient characteristics, tumour characteristics and survival. RESULTS: Three hundred eighty-nine patients with nvHCC [age 64(12-88) years; 344(88.4%) males] were screened. Median AFP was 25.46 ng/ml (1.16-100,000). 41.2% (n = 160) Of patients had normal AFP level. 22.9% (n = 89) had AFP over 400 ng/ml. Female gender (P < 0.05), vascular invasion (P < 0.001), tumours over 5 cm (P < 0.05), late TNM stage (P < 0.001) and non-surgical candidates had higher AFP levels. Diffuse type (P < 0.001), macro vascular invasion (P < 0.001) and late stage tumours (P < 0.001) had AFP over 400 ng/ml. Having AFP below 400 ng/ml was associated with longer survival (16 vs. 7 months, P < 0.001). CONCLUSION: Pre treatment AFP has a limited value In diagnosing nvHCC, Having a AFP value over 400 ng/ml was associated with aggressive tumour behaviour and poor prognosis.
URI: http://repository.kln.ac.lk/handle/123456789/18572
ISSN: 1471-230X (Electronic)
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